Crude fractions of aerial parts of Andrographis paniculata (Burm.f.) (Acanthaceae) were evaluated for antifeedant, growth-inhibitory and oviposition-deterrent activity against larval and adult stages of the Bihar hairy caterpillar, Spilarctia obliqua (Arctiidae). The methanol fraction had the highest growth-inhibitory activity. Further fractionation resulted in nine sub-fractions of which the most active, identified as the diterpene andrographolide, displayed significant growth-inhibitory and antifeedant properties with GI50 and FD50 values of 100.4 and 159.7 μg/g diet respectively. The ethyl acetate fraction possessed the highest oviposition-deterrent activity.