SARS-CoV-2 has become one of the most important and challenging medical research topics in recent years. The presence of endothelial dysfunction, immune thrombosis, and oxidative stress contributes to complications and requires more extended hospitalisation of patients. In this article, we focused on analysing the impact of oxidative stress on the severity of COVID-19 infection. The study group consisted of 72 patients with laboratory-confirmed SARS-CoV enrolled. The patients were divided into moderate and severe diseases according to the SCRI (Simple Covid Risk Index, including lymphocyte/D-dimer ratio). Using the ELISA kit, we determined the level of AOPP and 8-OHdG. Patients with severe COVID-19 had higher levels of both AOPP (P < 0.05) and 8-OHdG (P < 0.05) compared to patients with moderate disease. Albumin levels were significantly lower (P < 0.001), although fibrinogen (P < 0.01), D-dimer (P < 0.001), and TF (P < 0.05) levels were higher in severe patients than in moderate course. AOPP/Alb was also higher among severe patients (P < 0.05). Our data suggest a potential role for AOPP and 8-OHdG in predicting the outcome of SARS-CoV-2 patients. Elevated AOPP levels were associated with increased Dimer-D, TF, and vWF activity levels.

Field experiments were conducted in Auburn, AL in 2008 and 2009 to assess new aryloxyphenoxypropionate (AOPP) herbicides applied alone and tank-mixed with triclopyr for Tifway bermudagrass control in Zorro zoysiagrass. Treatments included three sequential applications of clodinafop (0.07 kg ai ha−1); triclopyr (1.12 kg ae ha−1); clodinafop + triclopyr (0.07 + 1.12 kg ha−1); fenoxaprop (0.10 kg ai ha−1); fenoxaprop + triclopyr (0.10 + 1.12 kg ha−1); metamifop (0.40 kg ai ha−1); and metamifop + triclopyr (0.40 + 1.12 kg ha−1). Clodinafop, fenoxaprop, and metamifop applied alone controlled Tifway bermudagrass 32 to 65% when rated 3 wk after the final application; however, the addition of triclopyr to these AOPP herbicides increased bermudagrass control to ≥ 89%. All AOPP herbicides applied alone caused unacceptable injury to Zorro zoysiagrass (20 to 42%) 3 wk after the final application. Clodinafop resulted in the greatest zoysiagrass injury (42%), whereas metamifop caused moderate injury (20%). Zorro zoysiagrass exhibited less injury (< 3%) and greater turf coverage (≥ 95%) when AOPP herbicides were tank-mixed with triclopyr. Of the three AOPP herbicides evaluated in this study, only fenoxaprop is currently labeled for use on turfgrass. However, the nonlabeled herbicides (clodinafop and metamifop) provided bermudagrass control and zoysiagrass safety equal to the commercial standard (fenoxaprop) 3 wk after the final application when tank-mixed with triclopyr. Where zoysiagrass is contaminated with bermudagrass, turf managers will likely have to make applications of AOPP herbicides tank-mixed with triclopyr over multiple years to control bermudagrass as it will continue to regrow from deep rhizomes.