This paper presents a brief overview of current human factors research into route guidance systems. A short description of different interface styles is given and a review of two road-based studies of three existing route guidance systems is provided. A general discussion then highlights a range of issues of relevance to driver-system interfaces, drawing on results both from the studies carried out, and other research. Specific aspects addressed include the content and means of presenting route guidance information, and the potential effect of interface design on driver visual behaviour and performance.