‘Uruq Bani Ma‘arid in Saudi Arabia is an Important Plant Area (IPA) in the Arabian Peninsula. This paper describes the flora of ‘Uruq Bani Ma‘arid, provides an up-to-date botanical checklist of the area, and gives background information on the geology and fauna. It designates the locality as an IPA due to the highest known levels of plant species diversity in the Empty Quarter and the presence of endemic Arabian taxa. In addition to conservation assessments, this study discusses socio-economic issues, threats to biodiversity conservation on ‘Uruq Bani Ma‘arid, and the future research required to build upon these preliminary studies. A new combination is made for Fagonia schweinfurthii.