The aim of this study is to track the evolution in the use of the markers nenny, non + verb (non fait ‘no, it doesn’t’) and non in its absolute use between the middle of the 15th century and the end of the 18th. In Middle French, non already covers all the uses of the old markers nenny and non fait, but it remains in the minority. In Pre-Classical French (1550–1650), the frequency of nenny and non fait decreases considerably and, in Classical French (1650–1789), they become archaic. In the mid-17th century, non definitively assumes the functions of the medieval markers, which disappeared. The analysis of the temporal distribution of these markers helps to date the transition from ancient to modern uses. Several studies of phonetic, morphological and syntactic phenomena have also aimed to date the turning point between the medieval and the “classical” language, which occurs during the so-called “pre-classical” period. This research also seeks to contribute to the debate on the position of the boundary between Pre-Classical and Classical French on the basis of pragmatic criteria. The results support placing this boundary within the decade 1620–1630, as other studies did for morphosyntactic phenomena.