Based on fieldwork conducted among the Buddhist population living in Rakhine State, Myanmar, between 2005 and 2011, this article elucidates how people deal with health and illness and related uncertainties by relying on a multiplicity of conceptions and practices associated with Buddhism, astrology, spirit cults, as well as indigenous and Western medicine. This article unpacks this plurality to show how different components contribute to the healing process in complementary and yet hierarchical ways which hold to a nexus of political, social, medical, economic, cosmological, biological, and environmental factors. It also questions the boundaries between the religious and medical, Buddhist and non-Buddhist, worldly and otherworldly, and natural and supernatural.