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Lewy body dementias (LBD) are the second most common dementia. Several genes have been associated with LBD, but little is known about their contributions to LBD pathophysiology. Each gene may transcribe multiple RNA, and LBD brains have extensive RNA splicing dysregulation. Hence, we completed the first transcriptome-wide transcript-level differential expression analysis of post-mortem LBD brains for gaining more insights into LBD molecular pathology that are essential for facilitating discovery of novel therapeutic targets and biomarkers for LBD. We completed transcript-level quantification of next-generation RNA-sequencing data from post-mortem anterior cingulate (ACC) and dorsolateral prefrontal cortices (DLPFC) of people with pathology-verified LBD (LBD = 14; Controls = 7) using Salmon. We identified differentially expressed transcripts (DET) using edgeR and investigated their functional implications using DAVID. We performed transcriptome-wide alternative splicing analysis using DRIMseq. We identified 74 DET in ACC and 96 DET in DLPFC after Benjamini-Hochberg false discovery rate (FDR) correction (5%). There were 135 and 98 FDR-corrected alternatively spliced genes in ACC and DLPFC of LBD brains, respectively. Identified DET may contribute to LBD pathology by altering DNA repair, apoptosis, neuroplasticity, protein phosphorylation, and regulation of RNA transcription. We confirm widespread alternative splicing and absence of chronic neuroinflammation in LBD brains. Transcript-level differential expression analysis can reveal specific DET that cannot be detected by gene-level expression analyses. Therapeutic and diagnostic biomarker potential of identified DET, especially those from TMEM18, MICB, MPO, and GABRB3, warrant further investigation. Future LBD blood-based biomarker studies should prioritise measuring the identified DET in small extracellular vesicles.
We determine the cohomology of the closed Drinfeld stratum of p-adic Deligne–Lusztig schemes of Coxeter type attached to arbitrary inner forms of unramified groups over a local non-archimedean field. We prove that the corresponding torus weight spaces are supported in exactly one cohomological degree and are pairwise non-isomorphic irreducible representations of the pro-unipotent radical of the corresponding parahoric subgroup. We also prove that all Moy–Prasad quotients of this stratum are maximal varieties, and we investigate the relation between the resulting representations and Kirillov’s orbit method.
The Critically Endangered Arabian leopard Panthera pardus nimr was believed to be absent from the Nejd region in Dhofar Governorate, Oman. However, a scat confirmed by DNA analysis in 2011 and camera-trap images from 2014 confirmed the presence of the leopard in this region. During 2014–2021, our camera traps documented at least eight individual leopards, demonstrating the species is resident and breeding in the region. This finding extends the Arabian leopard's known range in Oman by c. 40 km northwards. To improve detection probability, we recommend that camera-trap surveys for the leopard in the Arabian Peninsula are of at least 18 weeks duration. We advocate the designation of central and western areas of the Nejd as a National Nature Reserve, to protect critical habitat for the Arabian leopard and for other species in this region.
The evolving global order and regional dynamics have profoundly impacted China-Southeast Asia relations. As the world grapples with the geopolitical implications of intensified US-China competition, the Association of Southeast Asian Nations countries find themselves navigating a complex interplay of opportunities and challenges. The US-led Indo-Pacific strategy has significantly reshaped the geopolitical landscape, yet Southeast Asia’s relations with China are marked by interwoven challenges and opportunities. This special issue includes six papers that cover Malaysia, Vietnam, Thailand, Indonesia, Cambodia, and the Philippines, illustrating how small and medium-sized states navigate an increasingly multipolar world. A central theme across the papers in this special issue is the critical role of domestic factors in shaping each country’s relationship with China.
A 1st-c. CE lamp from Cyprus, now in the Metropolitan Museum of Art, features a discus design of a satyr on a base before an enclosure. Formerly identified as a nude silenus, the design on this lamp and others with the same decoration in fact illustrates a motif after the Forum Marsyas statue from the Forum Romanum. The statue is typically understood as a symbol of civic libertas, and copies were erected in provincial fora and depicted on civic coinage in the 2nd and 3rd c. CE. This note argues that the lamps enhance our understanding of the Forum Marsyas in two respects. First, the lamps demonstrate that the motif was in provincial circulation ahead of the sculptural and numismatic trend. Second, it is now clear that the Forum Marsyas was used in private contexts, and potentially with a non-civic meaning, more extensively than previously understood. The lamps are therefore significant for understanding the provincial spread and legibility of this important but still enigmatic motif.
The triangle removal states that if G contains $\varepsilon n^2$ edge-disjoint triangles, then G contains $\delta (\varepsilon )n^3$ triangles. Unfortunately, there are no sensible bounds on the order of growth of $\delta (\varepsilon )$, and at any rate, it is known that $\delta (\varepsilon )$ is not polynomial in $\varepsilon $. Csaba recently obtained an asymmetric variant of the triangle removal, stating that if G contains $\varepsilon n^2$ edge-disjoint triangles, then G contains $2^{-\operatorname {\mathrm {poly}}(1/\varepsilon )}\cdot n^5$ copies of $C_5$. To this end, he devised a new variant of Szemerédi’s regularity lemma. We obtain the following results:
• We first give a regularity-free proof of Csaba’s theorem, which improves the number of copies of $C_5$ to the optimal number $\operatorname {\mathrm {poly}}(\varepsilon )\cdot n^5$.
• We say that H is $K_3$-abundant if every graph containing $\varepsilon n^2$ edge-disjoint triangles has $\operatorname {\mathrm {poly}}(\varepsilon )\cdot n^{\lvert V(H)\rvert }$ copies of H. It is easy to see that a $K_3$-abundant graph must be triangle-free and tripartite. Given our first result, it is natural to ask if all triangle-free tripartite graphs are $K_3$-abundant. Our second result is that assuming a well-known conjecture of Ruzsa in additive number theory, the answer to this question is negative.
Our proofs use a mix of combinatorial, number-theoretic, probabilistic and Ramsey-type arguments.
Safe and effective navigation of the world's oceans and waterways relies on maritime education and training. This involves the learning of motor, procedural and verbal components of complex skills. Motor learning theory evaluates training variables, such as instructions, feedback and scheduling, to determine best practices for long-term retention of such skills. Motor learning theory has come a long way from focusing primarily on underlying cognitive processes to now including individual and contextual characteristics in making predictions about instructional strategies and their role in performance and learning. A remaining challenge in applying recent motor learning theory to maritime education and training is a lack of empirical testing of complex vocational skills, such as simulation scenarios, with delayed retention and transfer tests. Incorporating theory-based understanding of beneficial instructional practices, through both cognitive approaches and those considering context and environment, task complexity and learner characteristics is a fruitful way forward in advancing maritime education and training.
Around the turn of the twentieth century, U.S. newspapers began to address women specifically in separate sections, hoping to gather a female audience for advertisers. Scholarship on early twentieth-century women consumers tends to emphasize possibility and self-expression. Women’s reactions to the first women’s pages, by contrast, indicate that they could feel constrained and condescended to when welcomed into the public sphere on the basis of being consumers. Readers and journalists aired their grievances about the women’s page in its first decades, and sometimes found ways to use the page to their own ends. But publishers carried on designing women’s features with advertisers in mind. By the 1920s, the women’s page had become visually seductive, didactic, domestic, and relentlessly consumerist. This article uses the women’s page to investigate the rise of ad-subsidized media in the twentieth century and to weigh up the opportunities and costs of this media system.
In a time of unprecedented displacement, hostility toward refugees is widespread. Two common strategies refugee advocates pursue to counter hostility and promote inclusion are perspective-getting exercises and providing information that corrects misperceptions. In this study, we evaluate whether these strategies are effective across four outcomes commonly used to measure outgroup inclusion: warmth toward refugees, policy preferences, behavior, and beliefs about a common misperception concerning refugees. Using three studies with nearly 15,000 Americans, we find that information and perspective-getting affect different outcomes. We show that combining both interventions produces an additive effect on all outcomes, that neither strategy enhances the other, but that bundling the strategies may prevent backfire effects. Our results underscore the promise and limits of both strategies for promoting inclusion.
This paper explores the modernisation of rural Southern Italy between 1950 and 1962, focusing on the role of the Cassa per il Mezzogiorno, a public entity created to address the socio-economic divide between the North and South of Italy. The Cassa was central to the restructuring of rural areas, promoting land reclamation, infrastructure development, and the electrification of agricultural regions. The study examines how the ‘agrarian question’ intersected with the broader ‘Southern question’, reflecting persistent economic disparities within Italy. By analysing the early stages (1950–1962) of extraordinary intervention, this article demonstrates that modernisation efforts were aimed not only at reducing regional imbalances but also at addressing structural deficiencies that hindered agricultural productivity. While significant progress was made in modernising rural Southern Italy, this paper argues that the foundational agricultural reforms, although vital, needed to be complemented by broader industrial policies to ensure long-term socio-economic convergence with the more developed North.
To be effective, central bankers must project expertise and an anti-inflation commitment. However, those attributes are usually male-coded, which may undermine female central bankers. We assess gender bias using a survey experiment fielded in Japan in September 2022, when, for the first time in decades, the Bank of Japan appeared to struggle with inflation. We exposed individuals to simplified Bank of Japan communication and randomly assigned attribution to male (Mr. Adachi) or female (Ms. Nakagawa) Policy Board members. Respondents trusted the Bank of Japan less and were more sceptical of its capacity to handle inflation when Ms. Nakagawa represented it.
There is an unprecedented societal focus on young people’s mental health, including efforts to expand access to child and adolescent mental health services (CAMHS). There has, however, been a lack of research to date to investigate adult mental health outcomes of young people who attend CAMHS.
Methods
We linked Finland’s healthcare registries for all individuals born between 1987 and 1992. We investigated mental disorder diagnoses recorded in specialist adult mental health services (AMHS) and both inpatient and outpatient service use by age 29 (December 31, 2016) for former CAMHS patients.
Results
Before the end of their 20s, more than half (52.4%, n = 21,183) of all CAMHS patients had gone on to attend AMHS. The most prevalent recorded adult psychiatric diagnoses received by former CAMHS patients were depressive disorders (30%, n = 11,768), non-phobic anxiety disorders (21%, n = 7,910), alcohol use disorders (9.5%, n = 3,427), personality disorders (9.3%, n = 3,366), and schizophrenia-spectrum disorders (7.6%, n = 2,945). In the total population, more than half of all AMHS appointments (53.1%, k = 714,239/1,345,060) were for former CAMHS patients. More than half of all inpatient psychiatry bed days were for former CAMHS patients (53.1%, k = 1,192,991/2,245,247).
Conclusion
While there is a strong focus on intervening in childhood and adolescence to reduce the burden of mental illness, these findings suggest that young people who receive childhood intervention very frequently continue to require specialist psychiatric interventions in adulthood, including taking up a majority of both outpatient and inpatient service use. These findings highlight the need for a greater focus on research to alter the long-term trajectories of CAMHS patients.
The COVID-19 pandemic response made extraordinary demands on the public health workforce. In response to national studies and local observations about trauma in public health personnel, the Arizona Department of Health Services (ADHS) broadened the scope of their Health Emergency Operations Center (HEOC) Safety Officer position to include not only physical, but mental, emotional, and workplace health and safety. The new Health and Safety Officer (HSO) began in August 2022 and served through the end of the COVID-19 activation. The HSO advocated for staff, counseled HEOC leadership, and validated leadership’s prioritization of the health and wellness of HEOC staff. The impact of the HSO was felt within the HEOC and beyond, and this position should be considered a cost-effective, meaningful intervention in all jurisdictions to protect public health personnel. The HSO position is now a permanent part of the ADHS HEOC.
Validated yes/no vocabulary tests that measure bilinguals’ language proficiency based on vocabulary knowledge have been widely used in psycholinguistic research. However, it is unclear what aspects of test takers’ vocabulary knowledge are employed in these tests, which makes the interpretation of their scores problematic. The present study investigated the contribution of bilinguals’ form-meaning knowledge to their item accuracy on a Malay yes/no vocabulary test. Word knowledge of Malay first- (N = 80) and second-language (N = 80) speakers were assessed using yes/no, meaning recognition, form recognition, meaning recall and form recall tests. The findings revealed that 59% of the variance in the yes/no vocabulary test score was explained by the accuracy of the meaning recognition, form recognition and meaning recall tests. Importantly, the item analysis indicated that yes/no vocabulary tests assess primarily knowledge of form recognition, supporting its use as a lexical proficiency measure to estimate bilinguals’ receptive language proficiency.
Post-traumatic stress disorder (PTSD) is characterized by severe distress and associated with cardiometabolic diseases. Studies in military and clinical populations suggest that dysregulated metabolomic processes may be a key mechanism. Prior work identified and validated a metabolite-based distress score (MDS) linked with depression and anxiety and subsequent cardiometabolic diseases. Here, we assessed whether PTSD shares metabolic alterations with depression and anxiety and if additional metabolites are related to PTSD.
Methods
We leveraged plasma metabolomics data from three subsamples nested within the Nurses’ Health Study II, including 2835 women with 2950 blood samples collected across three time points (1996–2014) and 339 known metabolites assayed by mass spectrometry-based techniques. Trauma and PTSD exposures were assessed in 2008 and characterized as follows: lifetime trauma without PTSD, lifetime PTSD in remission, and persistent PTSD symptoms. Associations between the exposures and the MDS or individual metabolites were estimated within each subsample adjusting for potential confounders and combined in random-effects meta-analyses.
Results
Persistent PTSD symptoms were associated with higher levels of the previously developed MDS. Out of 339 metabolites, we identified 29 metabolites (primarily elevated glycerophospholipids and glycerolipids) associated with persistent symptoms (false discovery rate < 0.05; adjusting for technical covariates). No metabolite associations were found with the other PTSD-related exposures.
Conclusions
As the first large-scale, population-based metabolomics analysis of PTSD, our study highlighted shared and distinct metabolic differences linked to PTSD versus depression or anxiety. We identified novel metabolite markers associated with PTSD symptom persistence, suggesting further connections with metabolic dysregulation that may have downstream consequences for health.
How does the mass public form attitudes on electoral rules and reforms? Existing research on this question reveals a trade-off between principles, such as fairness, and partisan self-interest. I use two survey experiments on state legislative redistricting to explore how voters weigh principles against partisan self-interest when forming opinions on electoral reforms. First, I ask whether the public’s partisan self-interest motivation stems more from individual representation considerations or broader partisan power considerations. I find that both considerations provide a powerful enough incentive to activate partisan self-interest regarding preferences for state legislative district maps. Unexpectedly, the two considerations have quite similar effects on public support for redistricting reforms. Second, I explore the principles versus partisan self-interest trade-off through the lens of loss aversion, a concept developed in behavioral economics. In line with expectations, I find that preventing loss provides a more powerful incentive for Americans to violate democratic principles than achieving partisan gain. In sum, this research sheds light on voters’ decision between principles and partisan self-interest in the formation of opinion on electoral reform.
Based on experiences from stakeholders, this paper describes and discusses Danish emergency procedures when animal transport vehicles overturn, from a One Welfare perspective. Twenty qualitative interviews were conducted with selected stakeholders involved in emergency responses and their co-ordination. Results from interviews were extracted and are presented as a description of the Danish emergency management procedures in situations where pig transport vehicles overturn in a traffic accident. The description is followed by a discussion of six identified themes related to animal welfare and One Welfare in such situations: (1) Standard operating procedures; (2) Balancing animal welfare and work safety; (3) Roles, education and experience; (4) Communication, time and access to animals; (5) Debriefing; and (6) Killing of animals. Overall, the analyses of the interviews showed that the emergency response at an overturned pig transport vehicle involves different professional groups, requires technical knowledge regarding animal transport vehicles as well as knowledge of the species involved and how to handle the animals. The results are discussed from a One Welfare perspective, suggesting that these emergency responses include an inherent societal prioritisation dilemma involving the balancing of, for example, training, preparation and debriefing of different professional groups. Further research is needed to address ethical considerations, share best practices, and enhance emergency protocols.
This essay will discuss the issue of Native American history and periodization where we are not allowed “premodern” histories. History prior to European contact is relegated to terms like “Pre-Columbian” and consigned to the domain of archeologists. As a reclamation of Native sovereign ancestral presence, I am interested in public humanities as an interdisciplinary way to push against the myths and stereotypes that both confine Indigenous people to static pasts, either displacing ancestors into settler national memory or oblivion. My goals in public humanities are to work toward reclamations of ancient pasts in the so-called Americas from the limited imaginations of settler skull- and arrowhead-collectors toward reasserting the ongoing lived relationships that Natives have with spaces condemned as ruins and materials as relics. I briefly mention my own work in digital curation, Red Coral Stories, to provide counternarratives from European conquest toward expanding Native American presence across space and time.