Overview
The most robust genetic predictor of sporadic Alzheimer's disease (AD) is the ε4 allele of the apolipoprotein E (apoE) gene. This has spawned much interest into the relevance of this lipid-binding protein in this and other neuropsychiatric disorders and the roles it may play in the central nervous system (CNS). This symposium will present work examining the role of the apoE protein in neuronal function and CNS disorders focusing upon AD, schizophrenia and bipolar disorder. Novel data exploring both central and peripheral functions for apoE and its dysregulation will highlight the relevance of this protein in the pathology of these disorders.
