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Light-stimulated release of dopamine from the primate retina is blocked by l-2-amino-4-phosphonobutyric acid (APB)

Published online by Cambridge University Press:  01 January 1998

MEEUWIS K. BOELEN ,
MARY G. BOELEN  and
DAVID W. MARSHAK
MEEUWIS K. BOELEN
Affiliation:
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston
MARY G. BOELEN
Affiliation:
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston
DAVID W. MARSHAK
Affiliation:
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston
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Abstract

Macaca mulatta retinas were superfused, in vitro, to measure the efflux of dopamine. Steady light, in the low photopic range, stimulated dopamine release slightly. Flashing light (3 Hz) superimposed over the steady background increased dopamine efflux significantly. This increase was completely blocked by the addition of d,l-2-amino-4-phosphonobutyric acid (d,l-APB, 10–100 μM) to the superfusion medium, but not by the addition of the inactive enantiomer d-APB (10 μM). The results suggest that ON bipolar cells provide the excitatory drive to dopaminergic amacrine cells in primates, as in other species.

Keywords

Amacrine cellBipolar cellGlutamateMacaqueMonkey
Type
Research Article
Information
Visual Neuroscience , Volume 15 , Issue 1 , January 1998 , pp. 97 - 103
Copyright
1998 Cambridge University Press

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