Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-09T16:38:15.920Z Has data issue: false hasContentIssue false
  • English
  • Français

A topographic study of oscillatory potentials in man

Published online by Cambridge University Press:  02 June 2009

Shuang Wu  and
Erich E. Sutter
Shuang Wu
Affiliation:
Smith-Kettlewell Eye Research Institute, San Francisco
Erich E. Sutter
Affiliation:
Smith-Kettlewell Eye Research Institute, San Francisco
Get access Rights & Permissions [Opens in a new window]

Abstract

The purpose of this study was to evaluate the use of slow multifocal m-sequence stimulation in analyzing the topographic distribution and underlying mechanisms (including nonlinearities) of the retinal oscillatory potentials (OPs). In giving us access to the response topography and the nonlinear characteristics of the OP,, the m-sequence technique provides us with two important means for the identification and characterization of the signal sources. In this study, we analyzed the OPs into the first- and second-order components and investigated their topographies and luminance dependence. The distribution of both the first- and second-order OP components differed significantly from that of the nicker ERG investigated by Sutter and Tran (1992). At eccentricities and luminance levels favoring activity by both rods and cones, the second-order OPs were particularly prominent showing the most clear-defined and complex waveform The topographic distribution of the second-order OPs showed combined features of both rod and cone distributions On a strong rod-bleaching background the second-order OPs were eliminated and the first-order OPs showed a reduced amplitude and a shifted latency These results are consistent with the notion that the second-order component of the OPs is dominated by contributions from rod-cone interactions.

Keywords

ElectroretinogramOscillatory potentialsRetinal topographyRod-cone interactionTemporal nonlinearity
Type
Research Articles
Information
Visual Neuroscience , Volume 12 , Issue 6 , November 1995 , pp. 1013 - 1025
Copyright
Copyright © Cambridge University Press 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Algvere, P. & Wachtmeister, L. (1972). On the oscillatory potentials of the human electroretinogram in light and dark adaptation. II. Effect of adaptation to background light and subsequent recovery in the dark. A Fourier analysis. Acta Ophthalmologica 50, 837–862.CrossRefGoogle Scholar
Algvere, P. & Westbeck, S. (1972). Human ERG in response to double flashes of light during the course of dark adaptation: A Fourier analysis of the oscillatory potentials. Vision Research 12, 195–214.CrossRefGoogle Scholar
Blain, L., Lachapelle, P. & Molotchnikoff, S. (1990). The effect of acute trichloroethylene exposure on electroretinogram components. Neurotoxicology and Teratology 12, 633–636.CrossRefGoogle ScholarPubMed
Curcio, C.A., Sloan, K.R., Kalina, R.E. & Hendrickson, A.E. (1990). Human photoreceptor topography. Journal of Comparative Neurology 292, 497–523.CrossRefGoogle ScholarPubMed
Deschenes, M.C., Harnois, C., Bernier, J. & Bedard, J. (1990). Dopaminergic D2 antagonists: preferential action on the oscillatory potentials of the electroretinogram. Investigative Ophthalmology and Visual Sciences (Suppl.) 31, 334,(1643).Google Scholar
Gutte, P. & Lachapelle, P. (1990). The effect of 2-amino-4-phosphono-butyric acid on the oscillatory potentials of the electroreinogram. Documenta Ophthalmologica 75, 125–133.CrossRefGoogle Scholar
Heynen, H., Wachtmeister, L. & Norren, D.V. (1985). Origin of the oscillatory potentials in the primate retina. Vision Research 25, 1365–1373.CrossRefGoogle ScholarPubMed
King-Smith, P.E., Loffing, D.H. & Jones, R. (1986). Rod and cone ERGs and their oscillatory potentials. Investigative Ophthalmology and Visual Sciences 27, 270–273.Google ScholarPubMed
Lachapelle, P. (1990). Oscillatory potentials as predicators to amplitude and peak time of the photopic b-wave of the human electro-retinogram. Documenta Ophthalmologica 75, 73–82.CrossRefGoogle Scholar
Lachapelle, P. & Molotchnikoff, S. (1986). Components of the electroretinogram: A reappraisal. Documenta Ophthalmologica 63, 337–348.CrossRefGoogle ScholarPubMed
Lachapelle, P., Benoit, J., Little, J.M. & Faubert, J. (1990 a). The diagnostic use of the oscillatory potential in clinical electroretinog-raphy. Documenta Ophthalmologica 73, 327–336.CrossRefGoogle Scholar
Lachapelle, P., Benoit, J., Blain, L., Guite, P. & Roy, M.S. (1990 b). The oscillatory potentials in response to stimuli of photopic intensities delivered in dark-adaptation: An explanation for the conditioning flash effect. Vision Research 30, 503–513.CrossRefGoogle ScholarPubMed
Miyake, Y. (1990). Macular oscillatory potentials in humans. Documenta Ophthalmologica 75, 111–124.CrossRefGoogle ScholarPubMed
Ogden, T.E. (1973). The oscillatory waves of the primate electroretinogram. Vision Research 13, 1059–1074.CrossRefGoogle ScholarPubMed
Osterberg, G.A. (1935). Topography of the layer of rods and cones in the human retina. Acta Ophthalmologica (Suppl.) 6, 1–103.Google Scholar
Peachey, N.S., Alexander, K.R. & Fishman, G.A. (1987). Rod and cone system contributions to oscillatory potentials: an explanation for the conditioning flash effect. Vision Research 27, 859–866.CrossRefGoogle ScholarPubMed
Perry, V.H. & Cowey, A. (1985). The ganglion cell and cone distributions in the monkey≈s retina: Implications for central magnification factors. Vision Research 25, 1795–1810.CrossRefGoogle ScholarPubMed
Perry, V.H., Oehler, R. & Cowey, A. (1984). Retinal ganglion cells that project to the dorsal lateral geniculate nucleus in the macaque monkey. Neuroscience 12, 1101–1123.CrossRefGoogle Scholar
Speros, P. & Price, J. (1981). Oscillatory potentials. History, techniques and potential use in the evaluation of disturbances of retinal circulation. Survey of Ophthalmology 25, 237–252.CrossRefGoogle ScholarPubMed
Sutter, E.E. (1985). Multi-input VER and ERG analysis for objective perimetry. Proceedings: IEEE Engineering in Medicine and Biology Society, 7th Annual Conference, 414–419.Google Scholar
Sutter, E.E. (1987). A practical nonstochastic approach to nonlinear time-domain analysis. In Proceedings: Biomedical Simulations Resource, Advanced Methods of Physiological System Modeling, Vol. I, pp. 303–315. California: Biomedical Simulations Resource, University of Southern California.Google Scholar
Sutter, E.E. (1992). A deterministic approach to nonlinear systems analysis. In Nonlinear Vision, ed. Pinter, R.B. & Nabet, B., pp. 171–220. Cleveland, Ohio: CRC Press.Google Scholar
Sutter, E.E. & Tran, D. (1992). The field topography of ERG components in man: I. The photopic luminance response. Vision Research 32, 433–446.CrossRefGoogle Scholar
Wachtmeister, L. & Dowling, J.E. (1978). The oscillatory potentials of the mudpuppy retina. Investigative Ophthalmology and Visual Sciences 17, 1176–1188.Google ScholarPubMed
Yonemura, D., Aoki, T. & Tsuzuki, K. (1962). Electroretinogram in diabetic retinopathy. A.M.A. Archives of Ophthalmology 68, 49–54.Google ScholarPubMed