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Serotonin: 5-HT2A receptor occupancy in vivo and response to the new antipsychotics olanzapine and sertindole

Published online by Cambridge University Press:  03 January 2018

M. J. Travis ,
G. F. Busatto ,
L. S. Pilowsky ,
R. W. Kerwin ,
R. Mulligan ,
S. Gacinovic ,
D. C. Costa ,
P. J. Ell ,
J. Mertens  and
D. Terriere
M. J. Travis
Affiliation:
Section of Clinical Neuropharmacology, Institute of Psychiatry, Denmark Hill, London SE5 8AF
G. F. Busatto
Affiliation:
Section of Clinical Neuropharmacology, Institute of Psychiatry, Denmark Hill, London SE5 8AF
L. S. Pilowsky
Affiliation:
Section of Clinical Neuropharmacology, Institute of Psychiatry, Denmark Hill, London SE5 8AF
R. W. Kerwin
Affiliation:
Section of Clinical Neuropharmacology, Institute of Psychiatry, Denmark Hill, London SE5 8AF
R. Mulligan
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital, Mortimer Street, London WIN 8AA
S. Gacinovic
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital, Mortimer Street, London WIN 8AA
D. C. Costa
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital, Mortimer Street, London WIN 8AA
P. J. Ell
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital, Mortimer Street, London WIN 8AA
J. Mertens
Affiliation:
Vrije Universiteit Brussel – Eenheid, Cyclotron, B 1090 Brussel, Belgium
D. Terriere
Affiliation:
Vrije Universiteit Brussel – Eenheid, Cyclotron, B 1090 Brussel, Belgium
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Abstract

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Information
The British Journal of Psychiatry , Volume 171 , Issue 3 , September 1997 , pp. 290 - 291
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

References

Busatto, G. F., Pilowsky, L. S., Costa, D. C., et al (1997) Initial evaluation of 123-1-5-1-R91150, a selective 5-HT2A ligand for single photon emission tomography (SPET), in healthy human subjects. European Journal of Nuclear Medicine, 24, 119–142.Google Scholar
Kapur, S. & Remington, G. (1996) Serotonin–dopamine interaction and its relevance to schizophrenia. American Journal of Psychiatry, 153, 466–476.Google ScholarPubMed
Nyberg, S., Nakashima, Y., Nordstrom, A. L., et al (1996) Positron emission tomography studies of in vivo binding characteristics of atypical antipsychotic drugs. Review of D2 and 5-HT2 receptor occupancy studies and clinical response. British Journal of Psychiatry, 168 (suppl. 29), 40–44.Google Scholar
Pilowsky, L. S., Busatto, G. F., Taylor, M., et al (1996) Dopamine D2 receptor occupancy in vivo by the atypical antipsychotic olanzapine – a 123-11BZM single photon emission tomography (SPET) study. Psychopharmacology, 124, 148–153.Google Scholar
Pilowsky, L. S., O'Connell, P., Davies, N., (1997) In vivo occupancy of striatal D2 receptors by sertindole – a 123-11BZM SPET study. Journal of Psychopharmacology, 10 (suppl. 3), A9.Google Scholar
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