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Genetic Markers in Late Paraphrenia: A Study of HLA Antigens

Published online by Cambridge University Press:  02 January 2018

Mohsen Naguib ,
Peter McGuffm ,
Raymond Levy ,
Hilliard Festenstein  and
Antonio Alonso
Mohsen Naguib*
Affiliation:
University of Wales, College of Medicine
Peter McGuffm
Affiliation:
University of Wales, College of Medicine
Raymond Levy
Affiliation:
The Bethlem Royal and Maudsley Hospitals and the Institute of Psychiatry, London, Denmark Hill, London SE5 8AF
Hilliard Festenstein
Affiliation:
London Hospital Medical College
Antonio Alonso
Affiliation:
London Hospital Medical College
*
∗Senior Lecturer and Honorary Consultant Psychiatrist, St Charles Hospital, Exmoor Street, London W10
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Abstract

Patients with late paraphrenia were typed for HLA-A, -B and -C. Increased frequencies of BW55 (P= 0.036), B37 (P= 0.008) and CW6 (P=0.056) were found relative to controls. Unlike findings in paranoid schizophrenia, there was no HLAA9 association, suggesting that paraphrenics may be genetically distinct from schizophrenics. The primary association seems to be with B37, which has the lowest corrected P value and highest relative risk; if this were replicated, it would make possession of this antigen a strong risk factor for developing the disorder.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 150 , Issue 1 , January 1987 , pp. 124 - 127
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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