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Glucose Metabolic Rate in Normals and Schizophrenics During the Continuous Performance Test Assessed by Positron Emission Tomography

Published online by Cambridge University Press:  02 January 2018

Monte S. Buchsbaum ,
Keith H. Nuechterlein ,
Richard J. Haier ,
Joseph Wu ,
Nancy Sicotte ,
Erin Hazlett ,
Robert Asarnow ,
Stephen Potkin  and
Steven Guich
Monte S. Buchsbaum*
Affiliation:
Department of Psychiatry & Human Behavior, University of California, Irvine, Medical Sciences I, Room D-404, Irvine, California 92717
Keith H. Nuechterlein
Affiliation:
Psychiatry & Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, 1010 Westwood Boulevard, Los Angeles, California 90024, USA
Richard J. Haier
Affiliation:
Department of Psychiatry & Human Behavior, University of California, Irvine, Medical Sciences I, Room D-404, Irvine, California 92717
Joseph Wu
Affiliation:
Department of Psychiatry & Human Behavior, University of California, Irvine, Medical Sciences I, Room D-404, Irvine, California 92717
Nancy Sicotte
Affiliation:
Department of Psychiatry & Human Behavior, University of California, Irvine, Medical Sciences I, Room D-404, Irvine, California 92717
Erin Hazlett
Affiliation:
Department of Psychiatry & Human Behavior, University of California, Irvine, Medical Sciences I, Room D-404, Irvine, California 92717
Robert Asarnow
Affiliation:
Psychiatry & Biobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles, 1010 Westwood Boulevard, Los Angeles, California 90024, USA
Stephen Potkin
Affiliation:
Department of Psychiatry & Human Behavior, University of California, Irvine, Medical Sciences I, Room D-404, Irvine, California 92717
Steven Guich
Affiliation:
Department of Psychiatry & Human Behavior, University of California, Irvine, Medical Sciences I, Room D-404, Irvine, California 92717
*
∗Correspondence
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Abstract

Local cerebral uptake of glucose labelled with fluorine-18 was measured by positron emission tomography in 13 patients with schizophrenia and 37 right-handed volunteers. Patients received no medication for a minimum of 31 days and a mean of 30 weeks. The subjects were administered the labelled deoxyglucose just after the beginning of a 32-minute sequence of blurred numbers as visual stimuli for the Continuous Performance Test. In normal controls, task performance was associated with increases in glucose metabolic rate in the right frontal and right temporoparietal regions; occipital rates were unchanged. Patients with schizophrenia showed both absolutely and relatively reduced metabolic rates in the frontal cortex and in the temporoparietal regions compared with normal controls.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 156 , Issue 2 , February 1990 , pp. 216 - 227
Copyright
Copyright © Royal College of Psychiatrists, 1990

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