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Changes in Auditory P3 Event-related Potential in Schizophrenia and Depression

Published online by Cambridge University Press:  02 January 2018

D. H. R. Blackwood ,
L. J. Whalley ,
J. E. Christie ,
I. M. Blackburn ,
D. M. St Clair  and
A. McInnes
D. H. R. Blackwood*
Affiliation:
University of Edinburgh
I. M. Blackburn
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital
D. M. St Clair
Affiliation:
University of Edinburgh
A. McInnes
Affiliation:
EEG Department, Western General Hospital, Edinburgh
*
∗Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF
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Abstract

Event-related potentials during a two-tone discrimination task were recorded in 24 schizophrenic patients, 16 depressed patients and 59 control subjects. Recordings were made when patients were medication-free. Fourteen schizophrenic and 13 depressed patients were retested at 1 and 4 weeks after the start of treatment, and 13 schizophrenic patients were also tested between 6 and 24 months after the initial recordings. In the schizophrenic group, the P3 latency was significantly prolonged compared with that in the control and the depressed groups, and remained unchanged both after 4 weeks treatment with therapeutic doses of neuroleptic drugs and at long-term follow-up. In the depressed group, the P3 latency did not differ from that of controls. P3 amplitude by contrast was reduced in both the acutely depressed and schizophrenic groups and following treatment became normal in the depressed group but remained reduced in the schizophrenic group. It is suggested that a prolonged P3 latency and reduced P3 amplitude indicate an impairment of auditory information processing in some patients with schizophrenia which is independent of the presence of acute psychotic symptoms and is not influenced by neuroleptic medication.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 2 , February 1987 , pp. 154 - 160
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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