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Stress-related cognitive style is related to volumetric change of the hippocampus and FK506 binding protein 5 polymorphism in post-traumatic stress disorder

Published online by Cambridge University Press:  07 September 2020

Je-Yeon Yun ,
Min Jin Jin ,
Sungkean Kim  and
Seung-Hwan Lee Open the ORCID record for Seung-Hwan Lee [Opens in a new window]
Je-Yeon Yun
Affiliation:
Seoul National University Hospital, Seoul, Republic of Korea Yeongeon Student Support Center, Seoul National University College of Medicine, Seoul, Republic of Korea
Min Jin Jin
Affiliation:
Department of Psychiatry, Wonkwang University Hospital, Iksan, Republic of Korea Institute of General Education, Kongju National University, Gongju, Republic of Korea
Sungkean Kim
Affiliation:
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
Seung-Hwan Lee*
Affiliation:
Clinical Emotion and Cognition Research Clinical Emotion and Cognition Research Laboratory, Inje University, Goyang, Republic of Korea Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea
*
Author for correspondence: Seung-Hwan Lee, E-mail: [email protected]
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Abstract

Background

Patients with post-traumatic stress disorder (PTSD) show a different stress-related cognitive style compared with healthy controls (HC). The FK506 binding protein 5 gene (FKBP5), one of the PTSD known risk factors, is involved in the stress response through the hypothalamic-pituitary-adrenal axis and brain volumetric alterations. The present study aimed to uncover the neural correlates of stress-related cognitive styles through the analysis of the regional brain volumes and FKBP5 genotype in patients with PTSD compared with HC.

Methods

In this study, 51 patients with PTSD and 94 HC were assessed for stress-related cognitive styles, PTSD symptoms severity, and genotype of FKBP5 single nucleotide polymorphisms, and underwent T1-weighted structural magnetic resonance imaging. Diagnosis-by-genotype interaction for regional brain volumes was examined in 16 brain regions of interest.

Results

Patients with PTSD showed significantly higher levels of catastrophizing, ruminative response, and repression, and reduced distress aversion and positive reappraisal compared with HC (p < 0.001). Significant diagnosis-by-genotype interactions for regional brain volumes were observed for bilateral hippocampi and left frontal operculum. A significant positive correlation between the severity of the repression and left hippocampal volume was found in a subgroup of patients with PTSD with FKBP5 rs3800373 (AA genotype) or rs1360780 (CC genotype).

Conclusions

The present study showed the influences of FKBP5 genotype on the distorted cognitive styles in PTSD by measuring the volumetric alteration of hippocampal regions, providing a possible role of the hippocampus and left frontal operculum as significant neurobiological correlates of PTSD.

Keywords

FK506 binding protein 5 gene (FKBP5)hippocampuspost-traumatic stress disorderstress-related cognitive style
Type
Original Article
Information
Psychological Medicine , Volume 52 , Issue 7 , May 2022 , pp. 1243 - 1254
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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