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Parental depression and offspring psychopathology: a Children of Twins study

Published online by Cambridge University Press:  08 November 2010

A. L. Singh ,
B. M. D'Onofrio ,
W. S. Slutske ,
E. Turkheimer ,
R. E. Emery ,
K. P. Harden ,
A. C. Heath ,
P. A. F. Madden ,
D. J. Statham  and
N. G. Martin
A. L. Singh*
Affiliation:
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
B. M. D'Onofrio
Affiliation:
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
W. S. Slutske
Affiliation:
Department of Psychological Sciences, University of Missouri-Columbia, MO, USA
E. Turkheimer
Affiliation:
Department of Psychology, University of Virginia, Charlottesville, VA, USA
R. E. Emery
Affiliation:
Department of Psychology, University of Virginia, Charlottesville, VA, USA
K. P. Harden
Affiliation:
Department of Psychology, University of Virginia, Charlottesville, VA, USA
A. C. Heath
Affiliation:
School of Medicine, Washington University, St Louis, MO, USA
P. A. F. Madden
Affiliation:
School of Medicine, Washington University, St Louis, MO, USA
D. J. Statham
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia Faculty of Arts and Social Sciences, University of the Sunshine Coast, Queensland, Australia
N. G. Martin
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
*
*Address for correspondence: A. L. Singh, Ph.D., Department of Psychological and Brain Sciences, Indiana University, 1101 E. Tenth Street, Bloomington, IN 47405, USA. (Email: [email protected])
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Abstract

Background

Associations between parental depression and offspring affective and disruptive disorders are well documented. Few genetically informed studies have explored the processes underlying intergenerational associations.

Method

A semi-structured interview assessing DSM-III-R psychiatric disorders was administered to twins (n=1296) from the Australian Twin Register (ATR), their spouses (n=1046) and offspring (n=2555). We used the Children of Twins (CoT) design to delineate the extent to which intergenerational associations were consistent with a causal influence or due to genetic confounds.

Results

In between-family analyses, parental depression was associated significantly with offspring depression [hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.20–1.93] and conduct disorder (CD; HR 2.27, CI 1.31–3.93). Survival analysis indicated that the intergenerational transmission of depression is consistent with a causal (environmental) inference, with a significant intergenerational association in offspring of discordant monozygotic (MZ) twin pairs (HR 1.39, CI 1.00–1.94). Logistic regression analysis suggested that the parental depression–offspring CD association was due to shared genetic liability in the parents and offspring. No intergenerational association was found when comparing the offspring of discordant MZ twins [odds ratio (OR) 1.41, CI 0.63–3.14], but offspring of discordant dizygotic (DZ) twins differed in their rates of CD (OR 2.53, CI 0.95–6.76). All findings remained after controlling for several measured covariates, including history of depression and CD in the twins' spouses.

Conclusions

The mechanisms underlying associations between parental depression and offspring psychopathology seem to differ depending on the outcome. The results are consistent with a causal environmental role of parental depression in offspring depression whereas common genetic factors account for the association of parental depression and offspring CD.

Keywords

Children of twinsconduct disorderenvironmental riskgenetic liabilityparental depression
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 7 , July 2011 , pp. 1385 - 1395
Copyright
Copyright © Cambridge University Press 2010

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References

Beardslee, WR, Versage, EM, Gladstone, T (1998). Children of affectively ill parents: a review of the past 10 years. Journal of the American Academy of Child and Adolescent Psychiatry 37, 1134–1141.CrossRefGoogle ScholarPubMed
Bierut, LJ, Heath, AC, Bucholz, KK, Dinwiddie, SH, Madden, PAF, Statham, DJ, Dunne, MP, Martin, NG (1999). Major depressive disorder in a community-based twin sample: are there different genetic and environmental contributions for men and women? Archives of General Psychiatry 56, 557–563.CrossRefGoogle Scholar
Brennan, PA, Hammen, C, Katz, AR, Le Brocque, RM (2002). Maternal depression, paternal psychopathology, and adolescent diagnostic outcomes. Journal of Consulting and Clinical Psychology 70, 1075–1085.CrossRefGoogle ScholarPubMed
Bucholz, KK, Cadoret, R, Cloninger, CR, Dinwiddie, SH, Hesselbrock, VM, Nurnberger, JIJ, Reich, T, Schmidt, I, Schuckit, MA (1994). A new semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. Journal of Studies on Alcohol 55, 149–158.CrossRefGoogle ScholarPubMed
Cadoret, RJ, O'Gorman, TW, Heywood, E, Troughton, E (1985). Genetic and environmental factors in major depression. Journal of Affective Disorders 9, 155–164.CrossRefGoogle ScholarPubMed
Carragher, N, Adamson, G, Bunting, B, McCann, S (2009). Subtypes of depression in a nationally representative sample. Journal of Affective Disorders 113, 88–99.CrossRefGoogle Scholar
Connell, AM, Goodman, SH (2002). The association between psychopathology in fathers versus mothers and children's internalizing and externalizing behavior problems: a meta-analysis. Psychological Bulletin 128, 746–773.CrossRefGoogle ScholarPubMed
Cummings, EM, Keller, PS, Davies, M (2005). Towards a family process model of maternal and paternal depressive symptoms: exploring multiple relations with child and family functioning. Journal of Child Psychology and Psychiatry 46, 479–489.CrossRefGoogle ScholarPubMed
D'Onofrio, BM (2005). Children of Twins design. In Encyclopedia of Statistics in Behavioral Science (ed. Everitt, B. S. and Howell, D. C.), pp. 256–258. John Wiley & Sons, Ltd: Hoboken, N.J.Google Scholar
D'Onofrio, BM, Slutske, W, Turkheimer, E, Emery, R, Heath, A, Madden, PAF, Martin, NJ (2007 a). The intergenerational transmission of childhood conduct problems: a Children of Twins study. Archives of General Psychiatry 64, 820–829.CrossRefGoogle ScholarPubMed
D'Onofrio, BM, Turkheimer, E, Eaves, L, Corey, L, Berg, K, Solaas, MH, Emery, R (2003). The role of the Children of Twins design in elucidating causal relations between parent characteristics and child outcomes. Journal of Child Psychology and Psychiatry 44, 1130–1144.CrossRefGoogle ScholarPubMed
D'Onofrio, BM, Turkheimer, E, Emery, RE, Harden, KP, Slutske, WS, Heath, AC, Madden, PAF, Martin, NG (2007 b). A genetically informed study of the intergenerational transmission of marital instability. Journal of Marriage and Family 69, 793–809.CrossRefGoogle ScholarPubMed
D'Onofrio, BM, Turkheimer, E, Emery, R, Slutske, W, Heath, AC, Madden, P, Martin, N (2005). A genetically informed study of marital instability and its association with offspring psychopathology. Journal of Abnormal Psychology 114, 570–586.CrossRefGoogle ScholarPubMed
Eaves, L, Silberg, J, Maes, H (2005). Revisiting the Children of Twins: can they be used to resolve the environmental effects of dyadic parental treatment on child behavior? Twin Research and Human Genetics 8, 283–290.CrossRefGoogle ScholarPubMed
Eaves, LJ, Silberg, JL, Maes, HH, Simonoff, E, Pickles, A, Rutter, M, Neale, MC, Reynolds, CA, Erikson, MT, Heath, AC, Loeber, R, Truett, KR, Hewitt, JK (1997). Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. Journal of Child Psychology and Psychiatry and Allied Disciplines 38, 965–980.CrossRefGoogle ScholarPubMed
Eley, TC, Stevenson, J (1999). Exploring the covariation between anxiety and depression symptoms: a genetic analysis of the effects of age and sex. Journal of Child Psychology and Psychiatry and Allied Disciplines 40, 1273–1282.CrossRefGoogle ScholarPubMed
Foster, CE, Webster, MC, Weissman, MM, Pilowsky, DJ, Wickramarante, P, Rush, AJ, Hughes, CW, Garber, J, Malloy, E, Cerda, G, Kornstein, SG, Alpert, JE, Wisniewski, SR, Trivedi, MH, Fava, M, King, CA (2008). Course and severity of maternal depression: associations with family functioning and child adjustment. Journal of Youth and Adolescence 37, 906–916.CrossRefGoogle ScholarPubMed
Goodman, SH, Gotlib, IH (1999). Risk for psychopathology in the children of depressed mothers: a developmental model for understanding mechanisms of transmission. Psychological Review 106, 458–490.CrossRefGoogle ScholarPubMed
Goodman, SH, Tully, E (2006). Depression in women who are mothes: an integrative model of risk for the development of psychopathology in their sons and daughters. In Women and Depression: A Handbook for the Social, Behavioral, and Biomedical Sciences (ed. Keyes, C. L. M. and Goodman, S. H.), pp. 241–280. Cambridge University Press: New York.CrossRefGoogle Scholar
Gottesman, II, Bertelsen, A (1989). Confirming unexpressed genotypes for schizophrenia. Archives of General Psychiatry 46, 867–872.CrossRefGoogle ScholarPubMed
Harden, KP, Turkheimer, E, Emery, RE, D'Onofrio, BM, Slutske, WS, Heath, AC, Martin, NG (2007). Marital conflict and conduct disorder in Children-of-Twins. Child Development 78, 1–18.CrossRefGoogle ScholarPubMed
Harrington, R, Rutter, M, Fombonne, E (1996). Developmental pathways in depression: multiple meanings, antecedents, and endpoints. Development and Psychopathology 8, 601–616.CrossRefGoogle Scholar
Heath, AC, Bucholz, KK, Madden, PA, Dinwiddie, SH, Slutske, WS, Bierut, LJ, Statham, DJ, Dunne, MP, Whitfield, JB, Martin, NG (1997). Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychological Medicine 27, 1381–1396.CrossRefGoogle Scholar
Heath, AC, Kendler, KS, Eaves, LJ, Markell, D (1985). The resolution of cultural and biological inheritance: informativeness of different relationships. Behavior Genetics 15, 439–465.CrossRefGoogle ScholarPubMed
Heath, AC, Madden, PAF, Martin, NG (1998). Assessing the effects of cooperation bias and attrition in behavioral genetic research using data-weighting. Behavior Genetics 28, 415–427.CrossRefGoogle ScholarPubMed
Heath, AC, Martin, NG (1994). Genetic influences on alcohol consumption patterns and problem drinking: results from the Australian NHMRC Twin Panel Follow-Up Survey. Annals of the New York Academy of Sciences 708, 72–85.CrossRefGoogle Scholar
Jardine, R, Martin, NG (1984). Causes of variation in drinking habits in a large twin sample. Acta Geneticae Medicae et Gemellologiae 33, 435–450.CrossRefGoogle Scholar
Kane, P, Garber, J (2004). The relations among depression in fathers, children's psychopathology, and father-child conflict: a meta-analysis. Clinical Psychology Review 24, 339–360.CrossRefGoogle ScholarPubMed
Kendler, KS, Gardner, CO, Neale, MC, Prescott, CA (2001). Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychological Medicine 31, 605–616.CrossRefGoogle ScholarPubMed
Kendler, KS, Gardner, CO, Prescott, CA (1999). Clinical characteristics of major depression that predict risk of depression in relatives. Archives of General Psychiatry 56, 322–327.CrossRefGoogle ScholarPubMed
Lake, RI, Eaves, LJ, Maes, HH, Heath, AC, Martin, NG (2000). Further evidence against the environmental transmission of individual differences in neuroticism from a collaborative study of 45,850 twins and relatives on two continents. Behavior Genetics 30, 223–233.CrossRefGoogle Scholar
Lovejoy, MC, Graczyk, PA, O'Hare, E, Neuman, G (2000). Maternal depression and parenting behavior: a meta-analytic review. Clinical Psychology Review 20, 561–592.CrossRefGoogle ScholarPubMed
Maes, HHM, Neale, MC, Kendler, KS, Hewitt, JK, Silberg, JL, Foley, DL, Meyer, JM, Rutter, M, Simonoff, E, Pickles, A, Eaves, LJ (1998). Assortative mating for major psychiatric diagnoses in two population-based samples. Psychological Medicine 28, 1389–1401.CrossRefGoogle ScholarPubMed
Plomin, R, DeFries, JC, McClearn, Ge, McGuffin, P (2001). Behavior Genetics, 4th edn. Worth Publishers: New York.Google Scholar
Rhee, SH, Waldman, ID (2002). Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies. Psychological Bulletin 128, 490–529.CrossRefGoogle ScholarPubMed
Rice, F, Harold, GT, Thapar, A (2002). The genetic aetiology of childhood depression: a review. Journal of Child Psychology and Psychiatry 43, 65–79.CrossRefGoogle ScholarPubMed
Rice, F, Harold, GT, Thapar, A (2005). The link between depression in mothers and offspring: an extended twin analysis. Behavior Genetics 35, 565–577.CrossRefGoogle ScholarPubMed
Rutter, M (2007). Proceeding from observed correlation to causal inference: the use of natural experiments. Perspectives on Psychological Science 2, 377–395.CrossRefGoogle ScholarPubMed
Rutter, M, Pickles, A, Murray, R, Eaves, LJ (2001). Testing hypotheses on specific environmental causal effects on behavior. Psychological Bulletin 127, 291–324.CrossRefGoogle ScholarPubMed
Rutter, M, Silberg, J, O'Connor, T, Simonoff, E (1999). Genetics and child psychiatry: I. Advances in quantitative and molecular genetics. Journal of Child Psychology and Psychiatry 40, 3–18.CrossRefGoogle ScholarPubMed
Shadish, WR, Cook, TD, Campbell, DT (2002). Experimental and Quasi-Experimental Designs for Generalized Causal Inference. Houghton Mifflin: New York.Google Scholar
Silberg, JL, Maes, H, Eaves, LJ (2010). Genetic and environmental influences on the transmission of parental depression to children's depression and conduct disturbance: an extended Children of Twins study. Journal of Child Psychology and Psychiatry 51, 734–744.CrossRefGoogle ScholarPubMed
Slutske, WS, D'Onofrio, BM, Turkheimer, E, Emery, RE, Harden, KP, Heath, AC, Martin, NG (2008). Searching for an environmental effect of parental alcoholism on offspring alcohol use disorder: a genetically informed study of children of alcoholics. Journal of Abnormal Psychology 117, 534–551.CrossRefGoogle ScholarPubMed
Slutske, WS, Heath, AC, Dinwiddie, SH, Madden, PA, Bucholz, KK, Dunne, MP, Statham, DJ, Martin, NG (1997). Modeling genetic and environmental influences in the etiology of conduct disorder: a study of 2,682 adult twin pairs. Journal of Abnormal Psychology 106, 266–279.CrossRefGoogle Scholar
Sullivan, P, Neale, M, Kendler, K (2000). Genetic epidemiology of major depression: review and meta-analysis. American Journal Psychiatry 157, 1552–1562.CrossRefGoogle ScholarPubMed
Tully, E, Iacono, W, McGue, M (2008). An adoption study of parental depression as an environmental liability for adolescent depression and childhood disruptive disorders. American Journal of Psychiatry 165, 1148–1154.CrossRefGoogle ScholarPubMed
von Knorring, AL, Cloninger, CR, Bohman, M, Sigvardsson, S (1983). An adoption study of depressive disorders and substance abuse. Archives of General Psychiatry 40, 943–950.CrossRefGoogle ScholarPubMed
Wender, PH, Kety, SS, Rosenthal, D, Schulsinger, F, Ortman, J, Lunde, I (1986). Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. Archives of General Psychiatry 43, 923–929.CrossRefGoogle ScholarPubMed