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Does prostacyclin prevent cognitive deficits after open heart surgery?

Published online by Cambridge University Press:  09 July 2009

Elizabeth Pears ,
Richard Bowman ,
John Kincey  and
Ramji Gautam
Elizabeth Pears*
Affiliation:
Department of Psychiatry, University of Manchester, and Manchester Royal Infirmary, Manchester
Richard Bowman
Affiliation:
Department of Psychiatry, University of Manchester, and Manchester Royal Infirmary, Manchester
John Kincey
Affiliation:
Department of Psychiatry, University of Manchester, and Manchester Royal Infirmary, Manchester
Ramji Gautam
Affiliation:
Department of Psychiatry, University of Manchester, and Manchester Royal Infirmary, Manchester
*
1Address for correspondence: Ms Elizabeth Pears Department of Psychiatry, Stopford Building, University of Manchester, Manchester M13 9PT.
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Synopsis

Two groups of open heart surgery patients, one receiving prostacyclin and one placebo, were assessed one week pre-operatively and 3 months post-operatively, using a battery of clinical tests measuring a variety of cognitive functions. No significant differences between the groups were detected, apart from a visual retention deficit at 3 months in the prostacyclin group. The results cast doubt on previous findings suggesting that prostacyclin reduces cognitive deficits following open heart surgery.

Type
Brief Communication
Information
Psychological Medicine , Volume 14 , Issue 1 , February 1984 , pp. 213 - 214
Copyright
Copyright © Cambridge University Press 1984

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References

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