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Trial-Based Advances in the Treatment of Bipolar Depression

Published online by Cambridge University Press:  12 October 2006

David E. Kemp
Affiliation:
NIMH Bipolar Disorder Research Center, Mood Disorders Program, University Hospitals of Cleveland/Case Western Reserve University School of Medicine, Cleveland, OH, USA
Keming Gao
Affiliation:
NIMH Bipolar Disorder Research Center, Mood Disorders Program, University Hospitals of Cleveland/Case Western Reserve University School of Medicine, Cleveland, OH, USA
David J. Muzina
Affiliation:
NIMH Bipolar Disorder Research Center, Mood Disorders Program, University Hospitals of Cleveland/Case Western Reserve University School of Medicine, Cleveland, OH, USA
Prashant Gajwani
Affiliation:
NIMH Bipolar Disorder Research Center, Mood Disorders Program, University Hospitals of Cleveland/Case Western Reserve University School of Medicine, Cleveland, OH, USA
Joseph R. Calabrese
Affiliation:
NIMH Bipolar Disorder Research Center, Mood Disorders Program, University Hospitals of Cleveland/Case Western Reserve University School of Medicine, Cleveland, OH, USA

Abstract

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Type
Review Article
Copyright
© 2007 Cambridge University Press

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References

Practice guideline for the treatment of patients with bipolar disorder (revision) (2002). American Journal of Psychiatry, 159 (Suppl. 4), 150.
Akiskal, H.S., Bourgeois, M.L., Angst, J., Post, R., Moller, H., & Hirschfeld, R. (2000). Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. Journal of Affective Disorders, 59 (Suppl. 1), S5S30.CrossRefGoogle Scholar
Altshuler, L.L., Post, R.M., Leverich, G.S., Mikalauskas, K., Rosoff, A., & Ackerman, L. (1995). Antidepressant-induced mania and cycle acceleration: a controversy revisited. American Journal of Psychiatry, 152, 11301138.Google Scholar
Anand, A., Bukhari, L., Jennings, S.A., Lee, C., Kamat, M., Shekhar, A., Nurnberger Jr., J.I., & Lightfoot, J. (2005). A preliminary open-label study of zonisamide treatment for bipolar depression in 10 patients. Journal of Clinical Psychiatry, 66, 195198.CrossRefGoogle Scholar
Angst, J. (1998). The emerging epidemiology of hypomania and bipolar II disorder. Journal of Affective Disorders, 50, 143151.CrossRefGoogle Scholar
Baron, M., Gershon, E.S., Rudy, V., Jonas, W.Z., & Buchsbaum, M. (1975). Lithium carbonate response in depression. Prediction by unipolar/bipolar illness, average-evoked response, catechol-O-methyl transferase, and family history. Archives of General Psychiatry, 32, 11071111.CrossRefGoogle Scholar
Benazzi, F. (2000). Depression with DSM-IV atypical features: a marker for bipolar II disorder. European Archives of Psychiatry and Clinical Neuroscience, 250, 5355.CrossRefGoogle Scholar
Benazzi, F. (2001). Prevalence and clinical correlates of residual depressive symptoms in bipolar II disorder. Psychotherapy and Psychosomatics, 70, 232238.CrossRefGoogle Scholar
Bowden, C.L., Calabrese, J.R., Sachs, G., Yatham, L.N., Asghar, S.A., Hompland, M., Montgomery, P., Earl, N., Smoot, T.M., & DeVeaugh-Geiss, J. (2003). A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Archives of General Psychiatry, 60, 392400.CrossRefGoogle Scholar
Calabrese, J. (October 24, 2005). Quetiapine monotherapy for the treatment of bipolar depression: the BOLDER II study. Presented at the 2005 annual meeting of the European College of Neuropsychopharmacology (Amsterdam, The Netherlands).
Calabrese, J.R., Bowden, C.L., Sachs, G.S., Ascher, J.A., Monaghan, E., & Rudd, G.D. (1999). A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. Journal of Clinical Psychiatry, 60, 7988.CrossRefGoogle Scholar
Calabrese, J.R., Bowden, C.L., Sachs, G., Yatham, L.N., Behnke, K., Mehtonen, O.P., Montgomery, P., Ascher, J., Paska, W., Earl, N., & DeVeaugh-Geiss, J. (2003). A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. Journal of Clinical Psychiatry, 64, 10131024.CrossRefGoogle Scholar
Calabrese, J.R., Hirschfeld, R.M., Frye, M.A., & Reed, M.L. (2004). Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sample. Journal of Clinical Psychiatry, 65, 14991504.CrossRefGoogle Scholar
Calabrese, J.R., Keck Jr., P.E., Macfadden, W., Minkwitz, M., Ketter, T.A., Weisler, R.H., Cutler, A.J., McCoy, R., Wilson, E., & Mullen, J. (2005). A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression. American Journal of Psychiatry, 162, 13511360.CrossRefGoogle Scholar
Cohn, J.B., Collins, G., Ashbrook, E., & Wernicke, J.F. (1989). A comparison of fluoxetine imipramine and placebo in patients with bipolar depressive disorder. International Clinical Psychopharmacology, 4, 313322.CrossRefGoogle Scholar
Davis, L.L., Bartolucci, A., & Petty, F. (2005). Divalproex in the treatment of bipolar depression:a placebo-controlled study. Journal of Affective Disorders, 85, 259266.CrossRefGoogle Scholar
Dilsaver, S.C., Chen, Y.W., Swann, A.C., Shoaib, A.M., Tsai-Dilsaver, Y., & Krajewski, K.J. (1997). Suicidality, panic disorder and psychosis in bipolar depression, depressive-mania and pure-mania. Psychiatry Research, 73, 4756.CrossRefGoogle Scholar
Frankle, W.G., Perlis, R.H., Deckersbach, T., Grandin, L.D., Gray, S.M., Sachs, G.S., & Nierenberg, A.A. (2002). Bipolar depression: relationship between episode length and antidepressant treatment. Psychological Medicine, 32, 14171423.CrossRefGoogle Scholar
Frye, M.A., Ketter, T.A., Kimbrell, T.A., Dunn, R.T., Speer, A.M., Osuch, E.A., Luckenbaugh, D.A., Cora-Ocatelli, G., Leverich, G.S., & Post, R.M. (2000). A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. Journal of Clinical Psychopharmacology, 20, 607614.CrossRefGoogle Scholar
Goldberg, J.F., Burdick, K.E., & Endick, C.J. (2004). Preliminary randomized, double-blind, placebo-controlled trial of pramipexole added to mood stabilizers for treatment-resistant bipolar depression. American Journal of Psychiatry, 161, 564566.CrossRefGoogle Scholar
Goodwin, F.K., Murphy, D.L., & Bunney Jr., W.E. (1969). Lithium-carbonate treatment in depression and mania. A longitudinal double-blind study. Archives of General Psychiatry, 21, 486496.CrossRefGoogle Scholar
Guelti, J., & Calabrese, J. (2005). Efficacy and safety of the new antidepressant agomelatine in combination with mood stabilizer in bipolar I patients with a major depressive episode. Bipolar Disorders, 7 (Suppl. 2), 63.Google Scholar
Himmelhoch, J.M., Thase, M.E., Mallinger, A.G., & Houck, P. (1991). Tranylcypromine versus imipramine in anergic bipolar depression. American Journal of Psychiatry, 148, 910916.Google Scholar
Hlastala, S.A., Frank, E., Mallinger, A.G., Thase, M.E., Ritenour, A.M., & Kupfer, D.J. (1997). Bipolar depression: an underestimated treatment challenge. Depression and Anxiety, 5, 7383.3.0.CO;2-6>CrossRefGoogle Scholar
Judd, L.L., Akiskal, H.S., Schettler, P.J., Endicott, J., Maser, J., Solomon, D.A., Leon, A.C., Rice, J.A., & Keller, M.B. (2002). The long-term natural history of the weekly symptomatic status of bipolar I disorder. Archives of General Psychiatry, 59, 530537.CrossRefGoogle Scholar
Keck, P.E., Perlis, R.H., Otto, M.W., Carpenter, D., Ross, R., & Docherty, J.P. (2004). The Expert Consensus Guideline Series: Treatment of Bipolar Disorder 2004. Postgraduate Medicine Special Report, December 119.Google Scholar
Keck, P.E. Jr., Calabrese J.R., McQuade, R.D., Carson, W.H., Carlson, B.X., Rollin, L.M., Marcus, R.N., & Sanchez, R. (2006). A randomized, double-blind, placebo-controlled 26-week trial of aripiprazole in recently manic patients with bipolar II disorder. Journal of Clinical Psychiatry, 67, 626637.CrossRefGoogle Scholar
McIntyre, R.S., Mancini, D.A., McCann, S., Srinivasan, J., Sagman, D., & Kennedy, S.H. (2002). Topiramate versus bupropion SR when added to mood stabilizer therapy for the depressive phase of bipolar disorder: a preliminary single-blind study. Bipolar Disorders, 4, 207213.CrossRefGoogle Scholar
McIntyre, R.S., Brecher, M., Paulsson, B., Huizar, K., & Mullen, J. (2005). Quetiapine or haloperidol as monotherapy for bipolar mania – a 12-week, double-blind, randomised, parallel-group, placebo-controlled trial. European Neuropsychopharmacology, 15, 573585.CrossRefGoogle Scholar
Nahas, Z., Kozel, F.A., Li, X., Anderson, B., & George, M.S. (2003). Left prefrontal transcranial magnetic stimulation (TMS) treatment of depression in bipolar affective disorder: a pilot study of acute safety and efficacy. Bipolar Disorders, 5, 4047.CrossRefGoogle Scholar
Nemeroff, C.B., Evans, D.L., Gyulai, L., Sachs, G.S., Bowden, C.L., Gergel, I.P., Oakes, R., & Pitts, C.D. (2001). Double-blind, placebo-controlled comparison of imipramine and paroxetine in the treatment of bipolar depression. American Journal of Psychiatry, 158, 906912.CrossRefGoogle Scholar
Perugi, G., Akiskal, H.S., Lattanzi, L., Cecconi, D., Mastrocinque, C., Patronelli, A., Vignoli, S., & Bemi, E. (1998). The high prevalence of “soft” bipolar (II) features in atypical depression. Comprehensive Psychiatry, 39, 6371.CrossRefGoogle Scholar
Post, R.M. (2005). The impact of bipolar depression. Journal of Clinical Psychiatry, 66 (Suppl. 5), 510.Google Scholar
Post, R.M., Uhde, T.W., Roy-Byrne, P.P., & Joffe, R.T. (1986). Antidepressant effects of carbamazepine. American Journal of Psychiatry, 143, 2934.Google Scholar
Prien, R.F., Kupfer, D.J., Mansky, P.A., Small, J.G., Tuason, V.B., Voss, C.B., & Johnson, W.E. (1984). Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium carbonate – imipramine combination. Archives of General Psychiatry, 41, 10961104.CrossRefGoogle Scholar
Sachs, G.S., Lafer, B., Stoll, A.L., Banov, M., Thibault, A.B., Tohen, M., & Rosenbaum, J.F. (1994). A double-blind trial of bupropion versus desipramine for bipolar depression. Journal of Clinical Psychiatry, 55, 391393.Google Scholar
Shelton, R.C., & Stahl, S.M. (2004). Risperidone and paroxetine given singly and in combination for bipolar depression. Journal of Clinical Psychiatry, 65, 17151719.CrossRefGoogle Scholar
Smulevich, A.B., Khanna, S., Eerdekens, M., Karcher, K., Kramer, M., & Grossman, F. (2005). Acute and continuation risperidone monotherapy in bipolar mania: a 3-week placebo-controlled trial followed by a 9-week double-blind trial of risperidone and haloperidol. European Neuropsychopharmacology, 15, 7584.CrossRefGoogle Scholar
Suppes, T., Baldessarini, R.J., Faedda, G.L., & Tohen, M. (1991). Risk of recurrence following discontinuation of lithium treatment in bipolar disorder. Archives of General Psychiatry, 48, 10821088.CrossRefGoogle Scholar
Suppes, T., Dennehy, E.B., Hirschfeld, R.M., Altshuler, L.L., Bowden, C.L., Calabrese, J.R., Crismon, M.L., Ketter, T.A., Sachs, G.S., & Swann, A.C. (2005). The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder. Journal of Clinical Psychiatry, 66, 870886.CrossRefGoogle Scholar
Tohen, M., Vieta, E., Calabrese, J., Ketter, T.A., Sachs, G., Bowden, C., Mitchell, P.B., Centorrino, F., Risser, R., Baker, R.W., Evans, A.R., Beymer, K., Dube, S., Tollefson, G.D., & Breier, A. (2003). Efficacy of olanzapine and olanzapine–fluoxetine combination in the treatment of bipolar I depression. Archives of General Psychiatry, 60, 10791088.CrossRefGoogle Scholar
Tohen, M., Greil, W., Calabrese, J.R., Sachs, G.S., Yatham, L.N., Oerlinghausen, B.M., Koukopoulos, A., Cassano, G.B., Grunze, H., Licht, R.W., Dell'Osso, L., Evans, A.R., Risser, R., Baker, R.W., Crane, H., Dossenbach, M.R., & Bowden, C.L. (2005). Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial. American Journal of Psychiatry, 162, 12811290.CrossRefGoogle Scholar
Winsberg, M.E., DeGolia, S.G., Strong, C.M., & Ketter, T.A. (2001). Divalproex therapy in medication-naive and mood-stabilizer-naive bipolar II depression. Journal of Affective Disorders, 67, 207212.CrossRefGoogle Scholar
Zarate Jr., C.A., & Quiroz, J.A. (2003). Combination treatment in bipolar disorder: a review of controlled trials. Bipolar Disorders, 5, 217225.CrossRefGoogle Scholar
Zarate Jr., C.A., Payne, J.L., Singh, J., Quiroz, J.A., Luckenbaugh, D.A., Denicoff, K.D., Charney, D.S., & Manji, H.K. (2004). Pramipexole for bipolar II depression:a placebo-controlled proof of concept study. Biological Psychiatry, 56, 5460.CrossRefGoogle Scholar
Zarate Jr., C.A., Quiroz, J.A., Singh, J.B., Denicoff, K.D., De Jesus, G., Luckenbaugh, D.A., Charney, D.S., & Manji, H.K. (2005). An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression. Biological Psychiatry, 57, 430432.CrossRefGoogle Scholar
Zornberg, G.L., & Pope Jr., H.G. (1993). Treatment of depression in bipolar disorder: new directions for research. Journal of Clinical Psychopharmacology, 13, 397408.CrossRefGoogle Scholar