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Positive psychological determinants of treatment adherence among primary care patients

Published online by Cambridge University Press:  27 August 2014

Sheri A. Nsamenang
Affiliation:
Laboratory of Rural Psychological and Physical Health, Department of Psychology, East Tennessee State University, TN, USA
Jameson K. Hirsch*
Affiliation:
Laboratory of Rural Psychological and Physical Health, Department of Psychology, East Tennessee State University, TN, USA
*
Correspondence to: Jameson K. Hirsch, PhD., Laboratory of Rural Psychological and Physical Health, Department of Psychology, East Tennessee State University, 420 Rogers Stout Hall, 37614 TN, USA. Email: [email protected]
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Abstract

Background

Patient adherence to medical treatment recommendations can affect disease prognosis, and may be beneficially or deleteriously influenced by psychological factors.

Aim

We examined the relationships between both adaptive and maladaptive psychological factors and treatment adherence among a sample of primary care patients.

Methods

One hundred and one rural, primary care patients completed the Life Orientation Test-Revised, Trait Hope Scale, Future Orientation Scale, NEO-FFI Personality Inventory (measuring positive and negative affect), and Medical Outcomes Study General Adherence Scale.

Findings

In independent models, positive affect, optimism, hope, and future orientation were beneficially associated with treatment adherence, whereas pessimism and negative affect were negatively related to adherence. In multivariate models, only negative affect, optimism and hope remained significant and, in a comparative model, trait hope was most robustly associated with treatment adherence.

Implications

Therapeutically, addressing negative emotions and expectancies, while simultaneously bolstering motivational and goal-directed attributes, may improve adherence to treatment regimens.

Type
Research
Copyright
© Cambridge University Press 2014 

Introduction

Treatment adherence, or the degree to which a patient’s behavior matches recommendations from a health care provider (Schlenk et al., Reference Schlenk, Burke and Rand2001), is an essential component of achieving health-related goals and disease management. Yet, patient non-adherence ranges from 15% to 93%, and it is estimated that four out 10 patients forget, misunderstand, or ignore treatment recommendations (Martin et al., Reference Martin, Williams, Haskard and DiMatteo2005). Increased cost of health care, medical and psychosocial complications from disease, and poor quality of life are consequences of poor treatment adherence (Herriman and Cerretani, Reference Herriman and Cerretani2007); as well, it is approximated that the cost of non-adherence is $300 billion annually and 125 000 deaths, in the United States (DiMatteo, Reference DiMatteo2004). On the other hand, an average of 26% of patients, across various disease groups, achieves good health outcomes as a consequence of adhering to treatment recommendations (DiMatteo et al., Reference DiMatteo, Giordani, Lepper and Croghan2002). Treatment adherence has been associated with better outcomes for patients with alcohol dependence (Aguiar et al., Reference Aguiar, Neto, Lambaz, Chick and Ferrinho2012), headaches (Gaul et al., Reference Gaul, van Doorn, Webering, Dlugaj, Katsarava, Diener and Fritsche2011), obsessive compulsive disorder (Simpson et al., Reference Simpson, Maher, Wang, Bao, Foa and Franklin2011), and depression. (Sirey et al., Reference Sirey, Bruce and Kales2010).

Conceptually, according to the World Health Organization (WHO, 2003), treatment adherence is a multidimensional phenomenon that is affected by five dimensions: (1) social/economic factors such as lack of effective social support network, low level of education, and unemployment; (2) therapy-related factors such as duration of treatment, treatment side effects, and complexity of treatment regimens; (3) the health system/health care team dimension, which refers to patient–provider relationship, status of health insurance reimbursement, and health worker burn out; (4) disease condition-related factors such as symptom severity, prognosis, and level of disability; and, (5) the patient-related dimension, which is comprised of patient attitudes, knowledge, perceptions, expectations, and beliefs.

At the level of the individual patient, characteristics such as fear of side effects, confusion and skepticism about treatment, or feelings of pessimism or low mood (Milam et al., Reference Milam, Richardson, Marks, Kemper and Mccutchan2004; Brunton, Reference Brunton2011), may negatively affect treatment adherence. Conversely, cognitive-emotional contributors to adaptive health functioning include, among others, positive affect, optimism, hopefulness, and future orientation. Such psychological factors tend to be stable and pervasive, affecting an individual’s behaviors, thoughts and feelings (Allemand et al., Reference Allemand, Steiger and Hill2013), including health behaviors and motivation to engage in treatment (Bosley et al., Reference Bosley, Fosbury and Cochrane1995). Importantly, research evidence, as well as theoretical support, suggests ambivalence toward self-health may be amenable to change, and this might be accomplished by addressing several key cognitive-emotional elements – mood and outlook (Rutter and Quine, Reference Rutter and Quine2002).

As an example, positive affect is an amalgamation of experiences such as enjoyment, love, and contentment, whereas negative affect is comprised of components such as fear, anger, distress, and sadness (Moneta et al., Reference Moneta, Vulpe and Rogaten2012). According to the Broaden-and-Build model, positive emotional experiences may beneficially expand an individual’s cognitive and behavioral repertoire, including intellectual, social and physical resources, perhaps to include health behaviors and treatment adherence; conversely, negative affect might contribute to narrowing of an individual’s cognitions and behaviors and, consequently, hinder treatment adherence (Fredrickson, Reference Fredrickson2001). In fact, positive affect has been found to promote health behaviors such as self-regulation against smoking (Shmueli and Prochaska, Reference Shmueli and Prochaska2012), while negative affect has been associated with poor health information processing (Beckjord et al., Reference Beckjord, Finney Rutten, Arora, Moser and Hesse2008).

An expectancy of doubt versus confidence, rather than a mood, optimism is the general belief that the future will be positive, with positive outcomes to life experiences, whereas pessimism is the expectation of negative outcomes (Scheier and Carver, Reference Scheier and Carver1992). In general, optimism may promote health behaviors via active coping (Carver et al., Reference Carver, Scheier and Segerstrom2010); further, according to expectancy-value theory, optimists may be more likely to adhere to treatment recommendations because optimistic expectations about treatment may result in a valuing of, and motivation toward, health or treatment goals (Carver and Scheier, Reference Carver and Scheier1998). Pessimism, alternatively, has been associated with denial and behavioral disengagement (Carver et al., Reference Carver, Pozo, Harris, Noriega, Scheier, Robinson, Ketcham, Moffat and Clark1993), use of passive coping strategies, and poor health behavior (Kubzansky et al., Reference Kubzansky, Kubzansky and Maselko2004).

Health goals must often be strived for, and hopefulness is a crucial component of success in such endeavors. Conceptualized as a motivational process of identifying, planning for and working toward attainment of a goal (Snyder, Reference Snyder2002; Bruininks and Malle, Reference Bruininks and Malle2005), the construct of hope is closely associated with treatment adherence. Greater levels of hopefulness are associated with better overall health (Nekolaichuk et al., Reference Nekolaichuk, Jevne and Maguire1999), engagement in stroke aftercare (Arnaert et al., Reference Arnaert, Filteau and Sourial2006), and fewer depressive symptoms (Visser et al., Reference Visser, Loess, Jeglic and Hirsch2013). Conversely, hopelessness, is related to poor participation in treatment (Dunn et al., Reference Dunn, Stommel, Corser and Holmes-Rovner2009), poor quality of life (Pompili et al., Reference Pompili, Pennica, Serafini, Battuello, Innamorati, Teti, Girardi, Amore, Lamis, Aceti and Girardi2013), negative peceptions of health and health illness self-blame (Iliceto et al., Reference Iliceto, Pompili, Girardi, Lester, Vincenti, Rihmer, Tatarelli and Akiskal2010).

Perhaps intuitively, treatment adherence, as well as other pathways toward health-related goals and treatment adherence, may be dependent on extent of future orientation, or the ability for a person to envision expectations about and actions related to future goals (Nurmi, Reference Nurmi2005; Hirsch et al., Reference Hirsch, Duberstein, Conner, Heisel, Beckman, Franus and Conwell2006). The ability to anticipate potential future scenarios, including health situations, may have motivational consequences for current health behavior; specifically, forethought and desire of a particular outcome may encourage goal identification, planning, and commitment (Lens et al., Reference Lens, Paixao, Herrera and Grobler2012), including engagement in health promotion behaviors (Crockett et al., Reference Crockett, Weinman, Hankins and Marteau2009).

As a group, and across samples, positive affect, hope, optimism, and future orientation, and lower negative affect and pessimism, appear to be associated with self-determination and self-efficacy (Corrigan et al., Reference Corrigan, Angell, Davidson, Marcus, Salzer, Kottsieper, Larson, Mahoney, O’Connell and Stanhope2012), which may motivate and facilitate treatment adherence. Although the aforementioned cognitive-emotional characteristics have been extensively studied with regard to health behaviors, including treatment engagement, no previously published research has examined these factors in the primary care setting, where their manifestation may be different. Understanding the association of these characteristics to treatment adherence in this setting is a crucial first step toward development of targeted interventions to promote adherence to health regimens. As such, we hypothesized that positive affect, optimism, hopefulness and future orientation would be significantly positively related to treatment adherence; and negative affect and pessimism would be inversely related, to treatment adherence, at the bivariate level, and at the multivariate level covarying age, sex and race/ethnicity.

Methods

Participants

Participants (n=101) in this Institutional Review Board-approved study were recruited from a rural, primary care clinic serving working and uninsured patients, in a region of the United States identified as a Health Provider Shortage Area (Correll et al., 2011). Participants were primarily female (n=71; 71%), White (n=94; 94%), and had a mean age of 42.18 (SD=12.83). Our sample participants ranged from 18 to 64 years of age, and did not qualify for state-level insurance (Tenncare) or federal-level insurance (Medicare). Most participants (n=46; 47%) reported an annual income less than $20 000, and 27 participants (28%) earned less than $10 000; such incomes are not unexpected, as most of the nation’s rural, poor receive their health care services from primary care providers (Ferrer, Reference Ferrer2007). Further, six percent of our sample (n=6) did not graduate high school, and only 25 persons (25%) had obtained a college degree. Self-report data were collected over a one-year period through in-person and online survey administration. Participants completed an informed consent process, and those who completed the survey materials were compensated with $15.00.

Measures

The Medical Outcomes Study General Adherence Scale (MOS general adherence scale), a five-item measure, was used to assess general treatment adherence (Sherbourne et al., Reference Sherbourne, Hays, Ordway, DiMatteo and Kravitz1992). Items are rated on a 6-point Likert scale ranging from 1 (none of the time) to 6 (all of the time); for example, ‘generally speaking, how often during the past 4 weeks were you able to do what the doctor told you?’ The MOS general adherence scale has demonstrated acceptable internal reliability (α=0.78) (Kravitz et al., Reference Kravitz, Hays, Sherbourne, DiMatteo, Rogers, Ordway and Greenfield1993), including in primary care (α=0.88) (Hamilton, Reference Hamilton2003).

Trait positive affect and negative affect were assessed using the NEO Five-Factor Inventory (Costa and McCrae, Reference Costa and McCrae1992). Using sub-cluster item scoring, four items are utilized to assess trait positive affect and five items to assess trait negative affect (Chapman, Reference Chapman2007). Items are rated on a 5-point Likert scale ranging from ‘strongly disagree’ to ‘strongly agree’. In previous research with a clinical sample, positive affect (α=0.68) had moderate internal reliability and negative affect (α=0.78) had acceptable internal reliability (Hirsch et al., Reference Hirsch, Duberstein, Chapman and Lyness2007).

The Life Orientation Test-Revised (LOT-R) was used as a measure of dispositional optimism and pessimism (Scheier et al., Reference Scheier, Carver and Bridges1994). The LOT-R consists of 10 items which are rated on a 5-point Likert scale ranging from 0 (strongly disagree) to 4 (strongly agree). Three items measure optimism (eg, ‘Overall, I expect more good things to happen to me than bad’), three items measure pessimism (eg, ‘I rarely count on good things happening to me’), and four items are fillers (eg, ‘It’s important for me to keep busy’). The LOT-R demonstrated acceptable internal consistency for optimism (α=0.71) and moderate internal consistency of pessimism (α=0.68), in a primary care sample (Herzberg et al., Reference Herzberg, Glaesmer and Hoyer2006; Hirsch et al., Reference Hirsch, Walker, Wilkinson and Lyness2013).

Trait hope was measured by the composite score of the Trait Hope Scale (THS), which consists of eight items (Snyder et al., Reference Snyder, Harris, Anderson, Holleran, Irving, Sigmon, Yoshinobu, Gibb, Langelle and Harney1991). Items are rated on a 4-point Likert scale that ranges from 1 (definitely false) to 4 (definitely true); a sample item is: ‘there are lots of ways around any problem’. Internal consistency for the THS ranges from 0.74 to 0.84 (Curry et al., Reference Curry, Snyder, Cook, Ruby and Rehm1997), and the measure has been previously used in a primary care sample (Hirsch et al., Reference Hirsch, Sirois and Lyness2011).

Future orientation was measured using six items derived from the Reasons for Living Inventory-Older Adult Version (Edelstein et al., Reference Edelstein, Heisel, McKee, Martin, Koven, Duberstein and Britton2009). Items are rated on a Likert scale ranging from 1 (extremely unimportant) to 6 (extremely important); sample item is: ‘I have future plans I am looking forward to carrying out’. This scale has not been previously used with primary care patients but, in a clinical sample of depressed patients the six items demonstrated good internal consistency (α=0.91), with an average item-total correlation of 0.75 (Hirsch et al., Reference Hirsch, Duberstein, Conner, Heisel, Beckman, Franus and Conwell2006).

Statistical analyses

Pearson’s product-moment correlations were used to examine zero-order associations between, and independence of, study variables. No correlation coefficients exceeded the cut-off recommended for multicollinearity (r>0.80) (Katz, Reference Katz2006), and all variables were retained in analyses. Hierarchical linear regression analyses were used to examine individual predictors of treatment adherence while controlling for age and sex. Additional multivariate models were analyzed, entering clusters of psychological variables simultaneously: (i) positive affect and negative affect; (ii) optimism and pessimism; and, (iii) trait hope and future orientation, as predictors. Finally, a multivariate model, using stepwise linear regression, was used to explore relative robustness of predictors.

Power analyses were conducted to ensure adequate sample size and to reduce risk for Type I error (α) and Type II error (β) (Green, Reference Green1991; Tabachnick and Fidell, Reference Tabachnick and Fidell2007). For regression analyses and desired medium effects, α=0.05, and β=0.20, a sample size of n⩾50+8m is necessary to assess multiple correlations, where m refers to the number of independent variables in each model; our sample size of 101 exceeds the required 82 cases.

Results

In support of our hypotheses, at the bivariate level, greater positive affect (r=0.32, P=0.001), optimism (r=0.36, P<0.001), hopefulness (r=0.41, P<0.001), and future orientation (r=0.22, P=0.03) were associated with better self-reported treatment adherence. On the other hand, negative affect (r=−0.37, P<0.001) and pessimism (r=−0.32, P=0.001) were negatively related to treatment adherence (see Table 1).

Table 1 Means, standard deviations, and correlations

Optimism and pessimism=Life Orientation Test-Revised; Hopefulness=Trait Hope Scale; Future orientation=Future Orientation Scale; Positive affect and negative affect=NEO-FFI Personality Inventory; Treatment adherence=Medical Outcomes Study General Adherence Scale.

*P⩽0.05, **P⩽0.01.

In separate hierarchical regression analyses, pessimism, optimism, hopefulness, negative affect, and positive affect were independently associated with patient-reported treatment adherence. Meanwhile, future orientation was not significantly related to treatment adherence (see Table 2).

Table 2 Hierarchical multiple regression analyses of psychological factors affecting treatment adherence

Independent models=single IV; multivariable models=simultaneous IV’s. Optimism and pessimism=Life Orientation Test-Revised; Hopefulness=Trait Hope Scale; Future orientation=Future Orientation Scale; Positive affect and negative affect=NEO-FFI Personality Inventory; Treatment adherence=Medical Outcomes Study General Adherence Scale.

*P⩽0.05, **P⩽0.01, ***P⩽0.001. f 2=effect size: 0.02=small, 0.15=small, 0.35=large (Cohen, Reference Cohen1988).

In a multiple regression model, with simultaneous entry of the predictors of positive and negative affect, only negative affect was significantly related to treatment adherence. In a model combining pessimism and optimism, optimism was associated with treatment adherence. Finally, in a model simultaneously examining trait hope and future orientation, trait hope was significantly related to treatment adherence (see Table 2). In an exploratory model, using stepwise regression, trait hope emerged as the characteristic most robustly associated with treatment adherence (β=0.41; F(19.56), t=4.42, P<0.001).

Discussion

With a focus primarily on positive psychological variables amenable to brief treatment in primary care, we found that, after adjusting for age and sex in independent models, future orientation, optimism, pessimism, hope, negative, and positive affect were predictors of treatment adherence, supporting our hypotheses and previous research suggesting that treatment adherence is a multidimensional phenomenon affected by patient-related factors (WHO, 2003; Brunton, Reference Brunton2011). Most previous research on treatment adherence has focused on patient demographic and socio-economic factors (Rivero-Santana et al., Reference Rivero-Santana, Perestelo-Perez, Perez-Ramos, Serrano-Aguilar and De Las Cuevas2013), whereas our study focuses on psychological and motivational factors. In independent models, all cognitive-emotional characteristics were associated with treatment adherence in expected directions. When pairs of variables were analyzed simultaneously, negative affect, optimism, and hopefulness were more robustly associated with patient-reported treatment adherence, than were positive affect, pessimism, and future orientation. Finally, when model contribution was assessed, trait hope emerged as most robustly associated with treatment adherence. In sum, it appears that treatment adherence may benefit from reduction of negative emotions, bolstering positive expectancies and, particularly, establishing and working toward health-related goals.

Consistent with support for the beneficial effect of optimism on healthy behaviors and active coping (Waldrop et al., Reference Waldrop, Lightsey, Ethington, Woemmel and Coke2001; Solberg-Nes and Segerstrom, Reference Solberg-Nes and Segerstrom2006), our study suggests that optimism – even over and above the effects of pessimism – is associated with active treatment adherence. An optimistic belief that treatment recommendations will be successful, and that health or functionality will improve as a result, may increase treatment adherence (Karademas et al., Reference Karademas, Kynigopoulou, Aghathangelou and Anestis2011). Similarly, hopefulness, which is related to self-efficacy and strategic planning (Berg et al., Reference Berg, Ritschel, Swan, An and Ahluwalia2011), was associated with treatment adherence. From a theoretical perspective, hopefulness may facilitate personal efficacy in identification, planning and movement toward treatment and health-related goals (Tong et al., Reference Tong, Fredickson, Chang and Lim2010). Additionally, the goal-setting and motivational consequences of having positive expectations about the future may promote adaptive behavior engagement (Lens et al., Reference Lens, Paixao, Herrera and Grobler2012), such as treatment compliance. Conversely, individuals who are present-oriented or hold negative expectations about the future may have a limited sense of personal control (Crockett et al., Reference Crockett, Weinman, Hankins and Marteau2009), perhaps affecting engagement in adaptive future health behaviors.

In contrast to the adaptive characteristics of optimism and hope, we found that negative affect, which may involve symptoms of anger, anxiety, and depression was associated with poor treatment adherence (Beckjord et al., Reference Beckjord, Finney Rutten, Arora, Moser and Hesse2008; Grindley et al., Reference Grindley, Zizzi and Nasypany2008). Mechanistically, negative affect may constrict an individual’s thought-action repertoire and self-regulatory behaviors (Moskowitz et al., Reference Moskowitz, Shmueli‐Blumberg, Acree and Folkman2012), thus hindering the ability to adhere to treatment recommendations. Therapeutic efforts to reduce negative mood may be effective in encouraging patient involvement in the treatment process (Tice et al., Reference Tice, Baumeister, Shmueli and Muraven2007; Grindley et al., Reference Grindley, Zizzi and Nasypany2008). Curiously, both positive affect and future orientation failed to predict treatment adherence when included in multivariate models, suggesting that negative rather than positive affect, and that goal-orientation rather than simple future desires, are more robust contributors to treatment adherence.

Our novel findings must be interpreted in the context of minor limitations. Our sample of rural primary care patients was small, and was comprised of predominantly White females, which may limit generalizability. Further, because our volunteer participants self-selected into the study in response to flyers and brochures, we do not have information on the larger potential population from which our sample was drawn; thus, selection bias is possible, and sample representativeness is uncertain. Despite these issues, however, our sample was demographically similar to previous primary care samples (Probst et al., Reference Probst, Laditka, Moore, Harun, Powell and Baxley2006), as well as to residents of the geographic area surrounding the clinic data collection site, according to US Census estimates (2014). Finally, our use of self-report treatment adherence as an outcome is less than ideal, and may be subject to recall bias or social desirability effects, and our cross-sectional design limits the extent to which causal attributions can be discussed; therefore, our study should be replicated using objective, prospective assessments of diverse samples.

Previous research has strongly established the beneficial linkage between adaptive characteristics and health outcomes in medical samples; for instance, a supportive environment and social support network and positive affect are related to beneficial health outcomes including treatment adherence (DiMatteo, Reference DiMatteo1994; Reference DiMatteo2004; Hirsch et al., Reference Hirsch, Floyd and Duberstein2012); our study adds to this literature by expansion to a rural, primary care sample and by distinct focus on positive psychological functioning. In general, we found that positive psychological characteristics promote treatment adherence, and maladaptive psychological functioning, such as poor mood and outlook, are detrimental to compliance. Our findings may have clinical implications, which might be addressed by Behavioral Health Consultants in the primary care setting (Kolbasovsky et al., Reference Kolbasovsky, Reich and Romano2005). Decreasing negative affect, and increasing optimism and hopefulness, could be psychological targets that translate into better treatment adherence, perhaps via educational and affective interventions (Dolder, Reference Dolder, Lacro, Leckband and Jeste2003). Cognitive behavioral therapy strategies (Rains et al., Reference Rains, Penzien and Lipchik2006), such as re-appraisal of maladaptive cognitive distortions about treatment, and motivational interviewing techniques (Russell et al., Reference Russell, Cronk, Herron, Knowles, Matteson, Peace and Ponferrada2011), such as eliciting change talk and self-affirmation, may promote a sense of positive mood and adaptive future orientation that facilitates health goal-oriented behaviors including treatment adherence.

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Figure 0

Table 1 Means, standard deviations, and correlations

Figure 1

Table 2 Hierarchical multiple regression analyses of psychological factors affecting treatment adherence