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Resistance to intestinal parasites during murine AIDS: role of alcohol and nutrition in immune dysfunction

Published online by Cambridge University Press:  06 April 2009

R. R. Watson
R. R. Watson
Affiliation:
Alcohol Research Center, Department of Family and Community Medicine, University of Arizona, Tucson, AZ 85724, USA
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Summary

A murine AIDS model with many similarities to human AIDS, LP-BM5 Murine Leukaemia, suppresses T and B cell numbers and functions in the intestine. This permits chronic colonization by Giardia and Cryptosporidium. Cocaine and the nutrient alcohol, which are immunosuppressive, further reduce resistance to intestinal parasites and intestinal lymphocyte numbers. Protein undernutrition, vitamin E supplementation, and alcohol use further modify immune dysfunction induced by the murine retrovirus infection. This suggests that both undernutrition and nutrient supplementation could affect parasite resistance during AIDS. Thus this murine model of human AIDS has great potential to accelerate studies of the role of nutrients in immune dysfunction and resistance to intestinal parasites.

Keywords

CryptosporidiumGiardiaT-lymphocytesretrovirus
Type
Research Article
Information
Parasitology , Volume 107 , supplement S1: Human nutrition and parasitic infection , January 1993 , pp. S69 - S74
Copyright
Copyright © Cambridge University Press 1993

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References

REFERENCES

Alak, J. I. B., Shahbazian, M., Hebert, A. R., Huang, D. S., Wang, Y., Darban, H., Jenkins, E. M. & Watson, R. R. (1993 a). Humoral immune responses and resistance to Cryptosporidium parvum in a murine model of AIDS after chronic ethanol consumption. Advances in the Biosciences 86, 331–4.Google Scholar
Alak, J. I. B., Shahbazian, M., Huang, D. S., Wang, Y., Darban, H., Jenkins, E. M. & Watson, R. R. (1993 b). Alcohol and murine acquired immunodeficiency syndrome suppression of resistance to Cryptosporidium parvum infection during modulation of cytokine production. Alcoholism: Clinical and Experimental Research (in press).CrossRefGoogle Scholar
Ampel, N. M., Garewal, H. S., Watson, R. R., Probhala, R. H. & Dols, C. L. (1992). A preliminary trial of beta-carotene in subjects infected with the Human Immunodeficiency Virus. Journal of Nutrition 122, 728–32.Google Scholar
Basham, T., Holdener, T. & Merigan, T. (1991). Intermittent, alternating and concurrent regimens of zidovudine and 2–3 dideoxycytidine in the LP-BM5 murine induced immunodeficiency model. Journal of Infectious Diseases 163, 869–72.CrossRefGoogle ScholarPubMed
Chandra, R. K. (1992). Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 340, 1124–7.CrossRefGoogle ScholarPubMed
Darban, H., Enriquez, J., Sterling, C. R., Lopez, M. C., Chen, G. & Watson, R. R. (1991). Cryptosporidium growth enhanced by retrovirally-induced immunosuppression in mice infected with LP-BM5 murine leukemia virus. Journal of Infectious Diseases 16, 741–5.CrossRefGoogle Scholar
Gardner, M. B. (1990). Murine models of AIDS. In Animal Models of AIDS (ed. Schellekens, H. & Horzinek, M. C.), pp. 279–290. Elsevier Science Publishers.Google ScholarPubMed
Jolicoeur, P. (1991). Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis. FASEB Journal 5, 2398–405.CrossRefGoogle Scholar
Leonard-Green, T. K. & Watson, R. R. (1989). The AIDS-Immunocompetence-Nutrition Infection Cycle. In Cofactors in HIV-I Infection and AIDS (ed. Watson, R. R.), pp. 187–200. Boca Raton, FL; CRC Press.Google Scholar
Lopez, M. C., Colombo, L. L., Huang, D. S. & Watson, R. R. (1992). Suppressed mucosal lymphocyte populations by LP-BM5 murine leukemia virus infection producing murine AIDS. Regional Immunology 4, 162–7.Google ScholarPubMed
Lopez, M. C., Huang, D. S., Wang, Y., King, K. & Watson, R. R. (1993). Modulation of the intestinal immune system by ethanol and murine AIDS. Advances in the Biosciences 86, 299–304.Google Scholar
McMurray, D. N., Rey, V., Cassazza, L. J. & Watson, R. R. (1977). Effect of moderate malnutrition of concentrations of immunoglobulins and enzymes in tears of young Colombian children. American Journal of Clinical Nutrition 30, 1944–8.CrossRefGoogle ScholarPubMed
Odeleye, O. E. & Watson, R. R. (1991). The potential role of vitamin E in the treatment of immunologic abnormalities during Acquired Immune Deficiency Syndrome. Progress in Food & Nutrition Science 15, 1–19.Google ScholarPubMed
Odeleye, O. E., Eskelson, C. D., Mufti, S. I. & Watson, R. R. (1992). Vitamin E protection against chemically-induced esophageal tumor growth in mice immunocompromised by retroviral infection. Carcinogenesis 13, 1811–16.CrossRefGoogle ScholarPubMed
Petro, T. M., Darban, H. & Watson, R. R. (1993 a). Suppression of resistance to Giardia muris and cytokine production in a murine model of acquired immune deficiency syndrome. Regional Immunology 4, 409–14.Google Scholar
Petro, T. M., Watson, R. R., Feely, D. E. & Darban, H. (1993 b). Alcohol, cocaine, murine AIDS and resistance to Gardia. Advances in the Biosciences 86, 5–323.Google Scholar
Pillai, R. M. & Watson, R. R. (1991 a). AIDS: disease progression and immunomodulation by drugs of abuse and alcohol. AIDS Medical Report 4, 25–36.Google Scholar
Pillai, R. M. & Watson, R. R. (1991 b). Alcohol, sex and AIDS: a response. Alcohol & Alcoholism 25, 711–13.CrossRefGoogle Scholar
Shahbazian, L. M., Darban, H. R., Darban, J. R. & Watson, R. R. (1992). Influence of the level of dietary ethanol on resistance to Streptococcus pneumoniae in mice with murine AIDS. Alcohol & Alcoholism 27, 345–2.Google ScholarPubMed
Ungar, B. L., Ward, D. J., Fayer, R. & Quinn, C. A. (1990). Cessation of cryptosporidiosis-associated diarrhea in an acquired immunodeficiency syndrome patient after treatment with hyperimmune bovine colostrum. Gastroenterology 98, 486–9.CrossRefGoogle Scholar
Watson, R. R. (1989). Immunomodulation by alcohol: a cofactor in development of AIDS after retrovirus infection. In Cofactors in HIV-I Infection and AIDS, pp. 47–54. Boca Raton, FL: CRC Press.Google Scholar
Watson, R. R. (ed.) (1984). Nutrition, Disease Resistance, and Immune Function. New York: M. Dekker.Google Scholar
Watson, R. R. (1990). A murine retrovirus model for studies of the role of cofactors in AIDS development. In NIDA Research Monograph no. 96 (ed. Pham, P. T. K. & Rice, K.), pp. 166–180. Bethesda, MD.Google Scholar
Watson, R. R. (1992 a). Nutrition, immunomodulation and AIDS: an overview. Journal of Nutrition 122, 715–16.Google Scholar
Watson, R. R. (1992 b). LP-BM5, a murine model of AIDS: role of cocaine, morphine, alcohol and carotenoids in nutritional immunomodulation. Journal of Nutrition 122, 744–8.CrossRefGoogle ScholarPubMed
Watson, R. R., Chen, G. & Lopez, M. C. (1992). Effects of protein undernutrition and cocaine injection on T-lymphocyte numbers in retrovirally infected mice. Nutrition and Immunology (ed. Chandra, R. K.), pp. 269–82.Google Scholar
Watson, R. R., Wood, S., Wang, Y., Huang, D. S. & Lopez, M. C. (1993). Ethanol and murine retrovirus modulation of cytokine production by thymocytes. Advances in the Biosciences 86, 153–61.Google Scholar
Watzl, B. & Watson, R. R. (eds.) (1992). Alcohol and Nutrition. Boca Raton, FL: CRC Press.Google Scholar
Watzl, b. & Watson, R. R. (1993). Role of nutrients in alcohol-induced immunomodulation. Alcohol & Alcoholism. (In press.)Google ScholarPubMed
Watzl, B., Alak, J., Huang, D., Darban, H., Jenkins, E. M. & Watson, R. R. (1993). Enhancement of resistance to Cryptosporidium parvum by pooled bovine colostrum during murine retroviral infection. American Journal of Tropical Medicine and Hygiene. (In press.)Google Scholar