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High transversal relaxivities of silica coated multicore iron oxide nanoparticles suitable for magnetic resonance imaging

Published online by Cambridge University Press:  01 February 2011

Anna Roig ,
Elena Taboada  and
Elisenda Rodríguez
Anna Roig
Affiliation:
[email protected], Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Bellaterra, Spain
Elena Taboada
Affiliation:
[email protected], Institut d'Investigacions Biomèdiques de Barcelona (IIBM-CSIC), Barcelona, Spain
Elisenda Rodríguez
Affiliation:
[email protected], Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Bellaterra, Spain
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Abstract

We report on high transversal relaxivity values of composite iron oxide-silica nanoparticles. To obtain the material, pre-formed maghemite nanoparticles were coated with silica by sol-gel chemistry, using supercritical fluids as the reaction media. The composite particles were monodisperse and consisted of a core of several maghemite nanoparticles, surrounded by a thick silica shell. The high pressure and high temperature process did not affect the iron oxide particle size but induced an increase on their saturation magnetization values, possibly due to an improvement of the particle crystallinity. These iron oxide-based materials present very high transversal relaxivity values which can be correlated to the magnetic moment and to the silica shell width of the composite particles. Moreover, composite particles are not cytotoxic and they are dispersable in polar solvents.

Keywords

core/shellmagnetic propertiessol-gel
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1257: Symposium O – Multifunctional Nanoparticle Systems-Coupled Behavior and Applications , 2010 , 1257-O05-06
Copyright
Copyright © Materials Research Society 2010

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