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Using Antibodies to Make Images

Published online by Cambridge University Press:  14 March 2018

Stephen W. Carmichael
Stephen W. Carmichael*
Affiliation:
Mayo Clinic

Extract

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The atomic force microscope (AFM), the workhorse of scanning probe microscopes, has become even more versatile. Anneliese Raab, Wenhai Han, Dirk Badt, Sandra Smith-Gill, Stuart Lindsay, Hansgeorg Schindler, and Peter Hinterdorfer have demonstrated that the AFM, in the dynamic force mode, can use antibodies as a probe. Dynamic force microscopy uses a magnetized tip that is oscillated in an alternating magnetic field as the tip scans the surface. This provides a very gentile interaction that can be recorded as a high resolution topographic image. Raab et al., showed that more information can be obtained from the specimen.

Type
Research Article
Information
Microscopy Today , Volume 8 , Issue 3 , April 2000 , pp. 3 - 7
Copyright
Copyright © Microscopy Society of America 2000

References

Note

2. Raab, A., Han, W., Badt, D., Smith-Gill, S.J., Lindsay, S.W., Schindler, H., and Hinterdorfer, P., Antibody recognition imaging by force microscopy, Nature Biotechnology 17:902-905.Google Scholar