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Handling Creutzfeldt-Jakob Disease Tissues in the Histology Laboratory

Published online by Cambridge University Press:  14 March 2018

Michael Titford  and
Frank O. Bastian
Michael Titford
Affiliation:
University of South Alabama
Frank O. Bastian
Affiliation:
University of South Alabama

Extract

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Creutzfeldt-Jakob disease (CJD) resembles two other diseases, kuru (found in New Guinea tribesmen) and scrapie (found in sheep). CJD is a slow progressive dementia of the central nervous system. The transmissible agent of CJD is unusual for several reasons: it has a long incubation period, up to eight years in some cases; it does not provoke an inflammatory reaction within infected tissues; it has never been isolated; it is resistant to routine paraffin processing. Histotechnologists need to be informed of the potential hazards and of the correct handling of tissues infected with this unconventional agent, even though it has low transmissibility. Treatment of CJD tissues with long sterilization at high temperatures or prolonged exposure to bleach has proven effective in deactivating the agent. This article outlines the precautionary procedures used in our laboratory when processing CJD tissues. (J Histolechnol 12:214, 1989).

Type
Research Article
Information
Microscopy Today , Volume 6 , Issue 2 , March 1998 , pp. 22 - 27
Copyright
Copyright © Microscopy Society of America 1998

References

1. Brown, P, Gibbs, CJ, Gajdusek, DC, et al Transmission of Creutzfeldt-Jakob disease from formalin-fixed, paraffin-em bedded human brain tissue. N Eng J Med 315:1614, 1986.Google Scholar
2. Masters, CL, Gajdusek, DC, Gibbs, CJ: The familial occurrence of Creutzfeldt-Jakob disease and Alzheimer's disease, Brain 104:535, 1981.Google Scholar
3. Asher, DM, Gibbs, CJ, Gajdusek, DC: Slow viral infections: Safe handling of the agents of subacutespongiformencephalopathies; Chapter 10. In Laboratory Safety: principles and Practice, Miller, BM (ed), American Society of Microbiology, Washington, DC, 1966, p 59.Google Scholar
4. Gajdusek, DC, Gibbs, CJ, Asher, DM, et al Precautions in medical care of, and in handling materials from patients, with transmissible virus dementia (Creutzfeldt-Jakob disease). N Eng J Med 297:1253, 1977.Google Scholar
5. Robbins, SL, Cotran, RS, Kumar, V: Pathogenic Basis of Disease, 3rd edition, WB Saunders, Philadelphia, 1984.Google Scholar
6. Dinn, JJ: Slow infections - a challenge to traditional concepts. Irish Med J 78:293, 1985.Google Scholar
7. Narang, HK: Virus-like particles in Creutzfeldt-Jakob biopsy material. Ada Neuropathol (Berl) 32:163, 1975.Google Scholar
8. Bastian, FO: Spiroplasma-like inclusions in Creutzfeldt-Jakob disease. Arch Path Lab Med 103:665, 1979.Google Scholar
9. Merz, PA, Rohwer, RG, Kascsak, R, et al: Infection-specific particle from the unconventional slow virus diseases. Science 225:437, 1984.Google Scholar
10. Bastian, F, Jennings, R, Quindlen E: Spiroplasma-associated fibrils, JNeuropathol Exp Neurol 43:333, 1984.CrossRefGoogle Scholar
11. Bastian, FO. Jennings, RA, Gardner, WA: Antiserum to sera pie-associated fibril protein cross-reacts with spiroplasma mirum fibril proteins. J Clin Micr 25:2430, 1987.Google Scholar
12. Lampert, PW, Gajdusek, DC, Gibbs, CJ: Subacute spongiform virus encephalopathies, Am J Path 68:626, 1972.Google Scholar
13. Prusiner, SB: Prions. Sci Amer 251:50, 1984.Google Scholar
14. Manuelidis, L, Manuelidis, EE; Recent developments in scrapie and Creutzfeldt-Jakob disease. Prog Med Virol 33:78, 1986.Google Scholar
15. Bernoulli, C, Siegfried, J, Baumgartner, G, et al: Danger of accidental personto-person transmission of Creutzfeldt-Jakob disease by surgery, Lancet 1:478, 1977.CrossRefGoogle Scholar
16. Duffy, P, Wolf, J, Collins, G, et al: Possible person-to-person transmission of Creutzfeldt-Jakob disease. N Eng J Med 290:692, 1974.Google Scholar
17. Miller, DC: Creutzfeldt-Jakob disease in histopathology technicians. N Eng J Med 318:853, 1988.Google Scholar
18. Sitwell, L, Lach, B, Atack, E, et al: Creutzfeldt-Jakob disease in histopathology technicians, N Eng J Med 318:854, 1988.Google Scholar
19. Brown, P, Gibbs, CJ, Amyx, HL, et al: Chemical disinfection of Creutzfeldt-Jakob disease virus. N Eng J Med 306:1279, 1982.Google Scholar
20. Masters, CL, Jacobsen, PF, Kakulas, BA: Decontamination of formaldehydefixed tissues of Creutzfeldt-Jakob disease. J Neuropathol Exp Neurol 45:760, 1986.CrossRefGoogle Scholar
21. Masters, CL, Jacobsen, P, Kakulas, BA: Letter to the editor, J Neuropathol Exp Neural 44:304, 1985.CrossRefGoogle Scholar
22. Case Records of the Massachusetts General Hospital. (Case 45-1980) N Eng J Med 303:1161, 1980.Google Scholar
23. Armbrustmacher, VW: Armed Forces Institute of Pathology, Washington, DC, Personal Communication. Google Scholar