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Utilization of Optical Polarization Microscopy in the Study of Sorption Characteristics of Wound Dressing Host Materials

Published online by Cambridge University Press:  24 February 2014

Miha Devetak ,
Zdenka Peršin ,
Karin Stana-Kleinschek  and
Uroš Maver Open the ORCID record for Uroš Maver [Opens in a new window]
Miha Devetak*
Affiliation:
CE PoliMaT, Tehnološki park 24, SI-1000 Ljubljana, Slovenia
Zdenka Peršin
Affiliation:
CE PoliMaT, Tehnološki park 24, SI-1000 Ljubljana, Slovenia Faculty of Mechanical Engineering, Laboratory for Characterisation and Processing of Polymers, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia Member of Centre for Open Innovations and Research UM (CORE@UM)
Karin Stana-Kleinschek
Affiliation:
CE PoliMaT, Tehnološki park 24, SI-1000 Ljubljana, Slovenia Faculty of Mechanical Engineering, Laboratory for Characterisation and Processing of Polymers, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia Member of Centre for Open Innovations and Research UM (CORE@UM)
Uroš Maver
Affiliation:
CE PoliMaT, Tehnološki park 24, SI-1000 Ljubljana, Slovenia Member of Centre for Open Innovations and Research UM (CORE@UM) Faculty of Medicine, University of Maribor, Slomškov Trg 15, SI-2000 Maribor, Slovenia
*
*Corresponding author. [email protected]
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Abstract

Polarization microscopy was used for evaluation of kinetics of diclofenac sorption in three different wound dressing materials. The sorption kinetics can be evaluated by radii change and intensity of the light traveling through the fiber. The most frequently used host materials for drugs in wound dressings are alginate, polyesters such as polyethylene terephthalate, and viscose. We studied sorption of diclofenac as an example drug. Effective, but rather simple in vitro simulation of diclofenac sorption gives insight into the applicability of the mentioned materials for development of wound healing materials.

Keywords

polarization microscopyalginatePETviscosediclofenacsorption
Type
Biological Applications
Information
Microscopy and Microanalysis , Volume 20 , Issue 2 , April 2014 , pp. 561 - 565
Copyright
© Microscopy Society of America 2014 

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References

Alvarez-Lorenzo, C., Gomez-Ampza, J.L., Martinez Pacheco, R., Souto, C. & Concheiro, A. (2000). Interactions between hydroxypropylcelluloses and vapour/liquid water. Eur J Pharm Biopharm 50, 307–318.CrossRefGoogle ScholarPubMed
Demidova-Rice, T.N., Hamblin, M.R. & Herman, I.M. (2012). Acute and impaired wound healing: Pathophysiology and current methods for drug delivery, part 1: Normal and chronic wounds: Biology, causes, and approaches to care. Adv Skin Wound Care 25, 304–314.Google Scholar
Devetak, M., Skoporc, N., Rigler, M., Peršin, Z., Drevenšek Olenik, I., Čopič, M. & Stana-Kleinschek, K. (2012). Effects of plasma treatment on water sorption in viscose fibres. Mater Tehnol 46(1), 69–73.Google Scholar
Edwards, J.V., Buschle-Diller, G. & Goheen, S.C. (2006). Modified Fibers with Medical and Specialty Applications . Dordrecht, The Netherlands: Springer.Google Scholar
Fouda, I.M. & Seisa, E.A. (2008). Optomechanical properties of the morphology of viscose fibers due to the cold-drawing process. J Appl Polym Sci 110, 872–879.Google Scholar
Fouda, I.M. & Seisa, I.M. ( 2007). Birefringence and orientation parameters of cold-drawn viscose fibers. J Appl Polym Sci 106, 1768–1776.CrossRefGoogle Scholar
Goode, M.L.J. (2004). Psychological needs of patients when dressing a fungating wound: A literature review. J Wound Care 13, 380–382.Google Scholar
Hanna, J.R. & Giacopelli, J.A. (1997). A review of wound healing and wound dressing products. J Foot Ankle Surg 36, 2–14.CrossRefGoogle ScholarPubMed
Horstermann, H., Hentschke, R., Amkreutz, M., Hoffmann, M. & Wirts-Rutters, M.J. (2010). Predicting water sorption and volume swelling in dense polymer systems via computer simulation. Phys Chem B 114, 17013–17024.Google Scholar
Karoglou, M., Moropoulou, A., Giakoumaki, A. & Krokida, M.K. (2005). Capillary rise kinetics of some building materials. J Colloid Interface Sci. 284, 260–264.Google Scholar
Lin, S.Y., Chen, K.S. & Run-Chu, L. (2001). Design and evaluation of drug-loaded wound dressing having thermoresponsive, adhesive, absorptive and easy peeling properties. Biomaterials 22, 2999–3004.Google Scholar
Oldenbourg, R. (1996). A new view on polarization microscopy. Nature 381(8), 801–812.Google Scholar
Peršin, Z., Devetak, M., Drevenšek Olenik, I., Vesel, A., Mozetič, M. & Stana-Kleinschek, K. (2013). The study of plasma’s modification effects in viscose used as an absorbent for wound-relevant fluids. Carbohydr Polym 97(1), 143–151.CrossRefGoogle Scholar
Posthauer, M.E. (2006). Hydration: Does it play a role in wound healing? Adv Skin Wound Care 19, 74–76.CrossRefGoogle ScholarPubMed
Ross, S., Newton, R., Zhou, Y.M., Haffegee, J., Ho, M.W., Bolton, J.P. & Knight, D. (1997). Quantitative image analysis of birefringent biological material. J Microsc 187, 62–67.Google Scholar
Schueler, N., Russel, F.A. & McDougall, J.J. (2011). Topical diclofenac in the treatment of osteoarthritis of the knee. Orthop Res Rev 3, 1–8.Google Scholar
Sobolev, E.V., Sobolev, O.V. & Tikhonov, D.A. (2008). Online resource for theoretical study of hydration of biopolymers. SAR QSAR Environ Res 19, 303–315.Google Scholar
Weaver, R. (2003). Rediscovering Polarized Light Microscopy. Am Lab 35, 55–61.Google Scholar
Xie, Y., Hill, C.A.S., Jalaludin, Z. & Sun, D. (2011). The water vapour sorption behaviour of three celluloses: Analysis using parallel exponential kinetics and interpretation using the Kelvin-Voight viscoelastic model. Cellulose 18, 517–530.Google Scholar
Yang, Y., Kloczkowski., A., Mark, J.E., Erman, B. & Bahar, I. (1995). Experimental studies of elastomeric and optical properties and strain induced liquid-crystalline phase transitions, in deformed (hydroxypropyl) cellulose networks in the swollen state. Macromolecules 28, 4927.Google Scholar