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Ultrastructural Observations and Heat Shock Protein 70 in Induced Unilateral Abdominal Cryptorchh) Testis in Rats

Published online by Cambridge University Press:  02 July 2020

F. Al-Bagdadi ,
S. Farouqi ,
R. Stout ,
P. Crawford ,
J. Chandler ,
B. Eilts ,
D. Paccamonti ,
G. Hosgood ,
M. Kearny  and
D. Duffield
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F. Al-Bagdadi
Affiliation:
Department of Anatomy and Cell Biology
S. Farouqi
Affiliation:
Department of Pharmacology and Therapeutics, School of Medicine, Louisiana State University, Shreveport, LA, 71130-3932
R. Stout
Affiliation:
Department Laboratory Animal Medicine and Surgery
P. Crawford
Affiliation:
Department of Physiology, Pharmacology and Toxicology
J. Chandler
Affiliation:
Department of Dairy Science, Louisiana State University, Baton Rouge, LA, 70803-8408
B. Eilts
Affiliation:
Department Veterinary Clinical Sciences
D. Paccamonti
Affiliation:
Department Veterinary Clinical Sciences
G. Hosgood
Affiliation:
Department Veterinary Clinical Sciences
M. Kearny
Affiliation:
Department of Epidemiology, School of Veterinary Medicine
D. Duffield
Affiliation:
Department of Anatomy and Cell Biology
J. O'Donnell
Affiliation:
Department of Pharmacology and Therapeutics, School of Medicine, Louisiana State University, Shreveport, LA, 71130-3932
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Extract

Infertility has been reported to be a significant consequence of cryptorchidism. Testicular cancer has been increasing since the beginning of the century (2). It has been reported in men with unilateral cryptorchidism who develop cancer that 75% of the cases are in the undescended testis. In earlier reports, investigators found that almost half of the cryptorchid testis that developed testicular cancer were abdominal (3). The extent of the degenerative changes are more extensive in the abdominal testis than the inguinal testis (1). Heat shock proteins have been detected in normal as well as in heat treated testes (4, 7). It has been stated that unchecked heat shock protein leads to irreversible damage and ultimately cell death (6). Heat shock protein is used in this study as a marker. The long range objective of this study is to determine the sequence of the ultrastructural degenerative damages of the testis over specific periods in rats as a model and relate these changes to a comparable human age.

Type
Developmental and Reproductive Biology
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 175 - 176
Copyright
Copyright © Microscopy Society of America 1997

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References

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