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Ultrastructural and Histochemical Characterization of Secretory Granules in Human Lung Adenocarcinoma Cells

Published online by Cambridge University Press:  02 July 2020

R. G. Aktas ,
E. Demiralay ,
S. Altaner ,
L. Candan  and
A. K. Kutlu
R. G. Aktas
Affiliation:
Trakya University, Faculty of Medicine, Pathology Department, Edirne, 22030/, Turkey
E. Demiralay
Affiliation:
Trakya University, Faculty of Medicine, Pathology Department, Edirne, 22030/, Turkey
S. Altaner
Affiliation:
Trakya University, Faculty of Medicine, Pathology Department, Edirne, 22030/, Turkey
L. Candan
Affiliation:
Trakya University, Faculty of Medicine, Pathology Department, Edirne, 22030/, Turkey
A. K. Kutlu
Affiliation:
Trakya University, Faculty of Medicine, Pathology Department, Edirne, 22030/, Turkey
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Extract

Histochemical methods offer an excellent research tool for the characterization of glycoproteins in the secretory cells, thus contributing to the elucidation of the pathophysiology of different diseases. The different staining characteristics of mucins can be useful in diagnostic histopathology. It has been proposed that the reduction in sulphated glycoproteins and an increase in sialomucins in intestinal mucosa was an indicator of premalignant changes in carcinoma of the bowel. It has subsequently argued that this change may be consequence rather than a precursor of neoplasia. It may still be of some value as a marker of a premalignant change although it is somewhat variable. Previous studies have demonstrated the characterization of glycoproteins in different type of epitheloid cells in normal and pathologic conditions by using histochemical and electron microscopic techniques. However; little information has been available concerning the exact features of secretory granules in both normal and tumoral cells in lung.

Type
Biological Specimen Preparation/Cytochemistry/ Immunolabeling/Immunocytochemistry
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 480 - 481
Copyright
Copyright © Microscopy Society of America

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