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Ultrastructural and Biochemical Alterations in Rats Exposed to Crude Extract of Carex baccans and Potentilla fulgens

Published online by Cambridge University Press:  15 October 2012

Bishnupada Roy ,
Bikash Ranjan Giri ,
Mitali Chetia  and
Ananta Swargiary
Bishnupada Roy*
Affiliation:
Department of Zoology, North-Eastern Hill University, Shillong-793 022, Meghalaya, India
Bikash Ranjan Giri
Affiliation:
Department of Zoology, North-Eastern Hill University, Shillong-793 022, Meghalaya, India
Mitali Chetia
Affiliation:
Department of Zoology, North-Eastern Hill University, Shillong-793 022, Meghalaya, India
Ananta Swargiary
Affiliation:
Department of Zoology, North-Eastern Hill University, Shillong-793 022, Meghalaya, India
*
*Corresponding author. E-mail: [email protected]
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Abstract

The use of plants as a source of medicine is an important component of the health care system in rural India. Carex baccans (Cyperaceae) and Potentilla fulgens (Rosaceae) have been known since ancient times in northeast India for their antitumor, antidiabetic, and antihelmintic properties. The present study was designed to determine the subacute toxicity profile of the root tuber extract of C. baccans and root-peel extract of P. fulgens in Wistar rats. The subacute oral toxicity was conducted using sublethal doses of 40, 50, 100, 150, 200, and 400 mgkg−1 body weights. Surface topographical and ultrastructural observations of liver and intestinal microvilli showed remarkable deformation and disruption, accompanied by quantitative changes in the liver enzymes, i.e., aspartate aminotransferase and alanine aminotransferase in comparison to those of the control group. Apoptotic cell death was observed in the liver cells of rats exposed to both of the plant extracts. A significant increase in splenic lymphocyte count was also observed in rats exposed to the highest concentration of both extracts. The results showed that consumption of the plant extracts at higher doses may cause toxicological effect if treatment continues for a long time.

Keywords

antihelminticCarex baccansPotentilla fulgenssubacute toxicitysurface topographyultrastructure
Type
Biological Applications
Information
Microscopy and Microanalysis , Volume 18 , Issue 5 , October 2012 , pp. 1067 - 1076
Copyright
Copyright © Microscopy Society of America 2012

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