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Tramadol Biological Effects: 4: Effective Therapeutic Efficacy of Lagenaria siceraria Preparation (Gamal & Aref1) and Melatonin on Cell Biological, Histochemical, and Histopathological Changes in the Kidney of Tramadol-Induced Male Mice

Part of: Micrographia Collection

Published online by Cambridge University Press:  08 April 2021

Abdel-Baset M. Aref ,
Maha A. Momenah ,
Mariam M. Jad ,
Margit Semmler ,
Hoda S. Mohamedaiin ,
Ahmed Ahmed  and
Dalia Mohamedien Open the ORCID record for Dalia Mohamedien [Opens in a new window]
Abdel-Baset M. Aref*
Affiliation:
Cell Biology and Histochemistry Division, Zoology Department, Faculty of Science, South Valley University, Qena, Egypt Institutional Animal Care and Use Committee of South Valley University (IACUC-SVU), Qena, Egypt
Maha A. Momenah
Affiliation:
Zoology Department, Faculty of Science, Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
Mariam M. Jad
Affiliation:
Cell Biology and Histochemistry Division, Zoology Department, Faculty of Science, South Valley University, Qena, Egypt Institutional Animal Care and Use Committee of South Valley University (IACUC-SVU), Qena, Egypt
Margit Semmler
Affiliation:
Institutional Animal Care and Use Committee of South Valley University (IACUC-SVU), Qena, Egypt Diabetes Research Institute, Düsseldorf University, Düsseldorf, Germany
Hoda S. Mohamedaiin
Affiliation:
Institutional Animal Care and Use Committee of South Valley University (IACUC-SVU), Qena, Egypt Zoology Department, Faculty of Science, South Valley University, Qena, Egypt
Ahmed Ahmed
Affiliation:
Urology Department, Faculty of Medicine, Aswan University, Aswan, Egypt
Dalia Mohamedien
Affiliation:
Histology Department, Faculty of Veterinary, South Valley University, Qena, Egypt
*
*Author for correspondence: Abdel-Baset M. Aref, E-mail: [email protected]; [email protected]
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Abstract

Tramadol is used worldwide and is listed in many medical guidelines to treat both acute and chronic pains. There is a growing evidence of abuse of tramadol in some African and West Asian countries. Tramadol has some side effects. The present study designed to follow up the treatment of the cellular responses which might be induced in the kidney of tramadol mice. Treated mice received daily injection of tramadol dose (125 μg/100 g b.wt) for 20 and 40 days. Other mice received tramadol for 40 days and then were divided into three groups: the first received distilled water, the second received Lagenaria siceraria, and the third received melatonin daily for 40 days. Both the daily injection of tramadol for 20 and 40 days resulted in radical, extensive, and severe alterations in the normal histological architecture of the kidney. Treatment with Lagenaria siceraria or melatonin after tramadol administration for a long-term, markedly changed the collagen content and other chemical components, that may reach nearly normal levels. Such findings propose that although tramadol has many cytological and histopathological side effects on the kidneys of male mice, the treatments via Lagenaria siceraria and melatonin have effective therapeutic impacts on the tramadol side effects.

Keywords

cell biologyhistochemistryhistopathologykidneyLagenaria sicerariamale micemelatonintramadol
Type
Micrographia
Information
Microscopy and Microanalysis , Volume 27 , Issue 3 , June 2021 , pp. 613 - 625
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

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References

Abdeen, AM, Amer, TA, EL-Habibi, M & Kamal, EM (1994). Histological and histochemicals studies on the effect of fenvalrate insecticide on some organs of albino mice. J Union Arab Biol 2A, 129–166.Google Scholar
Acuna-Castroviejo, D, Escames, G, Rodriguez, MI & Lopez, LC (2007). Melatonin role in the mitochondrial function. Front Biosci 12, 947–963.CrossRefGoogle ScholarPubMed
Ali, HA, Afifi, M, Saber, TM, Makki, AA, Keshta, AT, Baeshen, B & AL-Farga, A (2020). Neurotoxic, hepatotoxic and nephrotoxic effects of tramadol administration in rats. J Mol Neurosci 70, 1934–1942.CrossRefGoogle ScholarPubMed
Aref, AM, Momenah, MA, Jad, MM & Semmler, M (2018). Tramadol biological effects: I: Effective therapeutic efficacy of Lagenaria siceraria preparation (Gamal & Aref1) and melatonin on cell biological, histochemical and histopathological changes in ileum of tramadol-induced male mice. Egypt Acad J Biolog Sci C Physiol & Mol Biol 10(2), 99–124.Google Scholar
Aslam, M & Najam, R (2013). A review of pharmacognostical, phytochemical and pharmacological properties of Lagenaria siceraria: A miracle herb. Int J Biomed Adv Res 4(5), 266–274.Google Scholar
Atici, S, Cinel, I, Cinel, L, Doruk, N & Eskandari, GU (2005). Liver and kidney toxicity in chronic use of opioids: An experimental long term treatment models. J Biosci 30(2), 245–252.CrossRefGoogle Scholar
Cao, R, Jia, J, Ma, X, Zhou, M & Fei, H (2013). Membrane localized iridium (III) complex induces endoplasmic reticulum stress and mitochondria-mediated apoptosis in human cancer cells. J Med Chem 56(9), 3636–3644.CrossRefGoogle ScholarPubMed
Carrasco, C, Marchena, AM, Holguín-Arévalo, MS, Martín-Partido, G, Rodríguez, AB, Paredes, SD & Pariente, JA (2013). Anti-inflammatory effects of melatonin in a rat model of caerulein-induced acute pancreatitis. Cell Biochem Funct 31(7), 585–590.Google Scholar
Carrillo-Vico, A, Guerrero, JM, Lardone, PJ & Reiter, RJ (2005). A review of the multiple action of melatonin on the immune system. Endocrine 27(2), 189–200.CrossRefGoogle ScholarPubMed
Ceccarelli, I, De Padova, AM, Fiorenzani, P, Massafra, C & Aloisi, AM (2006). Single opioid administration modifies gonadal steroids in both the CNS and plasma of male rats. Neuroscience 140(3), 929–937.CrossRefGoogle ScholarPubMed
Chen, W, Shockcor, JP, Tonger, R, Hunter, A, Gartner, C & Nelson, SD (1999). Protein and nonprotein cysteinyl thiol modification by N-acetyl-p-benzoquinone imine via a novel ipso adduct. Biochemistry 38, 8159–8166.CrossRefGoogle Scholar
Collet, BJ (2001). Chronic opioid therapy for non-cancer pain. Br J Anaesth 87, 133–143.CrossRefGoogle Scholar
Deshpande, S, Basil, MD & Basil, DZ (2009). Factors influencing healthy eating habits among college students: An application of the health belief model. Health Mark Q 26(2), 145–164.CrossRefGoogle ScholarPubMed
Gangwal, A, Parmar, SK, Gupta, GL, Rana, AC & Sheth, NR (2008). Immunomodulatory effects of Lagenaria siceraria fruits in rats. Pharmacogn Mag 4(16), 234–238.Google Scholar
Ghosh, K, Chandra, K, Ojha, AK, Sarkar, S & Islam, SS (2009). Structural identification and cytotoxic activity of a polysaccharide from the fruits of Lagenaria siceraria. Carbohyd Res 344(5), 693–698.CrossRefGoogle ScholarPubMed
Hall, AJ, Logan, JE, Toblin, RL, Kaplan, JA, Kraner, JC, Bixler, D, Crosby, AE & Paulozzi, LJ (2008). Patterns of abuse among unintentional pharmaceutical overdose fatalities. JAMA 300(22), 2613–2620.CrossRefGoogle ScholarPubMed
Holden, JE, Jeong, Y & Forrest, JM (2005). The endogenous opioid system and clinical pain management. AACN Clin Issues 16, 291–301.CrossRefGoogle ScholarPubMed
Jarrar, B & Taib, N (2012). Histological and histochemical alterations in the liver induced by lead chronic toxicity. Saudi J Biol Sci 19(2), 203–210.CrossRefGoogle ScholarPubMed
Kumar, KV, Naidu, MUR, Shifow, AA, Prayag, A & Ratnakar, KS (1999). Melatonin: An antioxidant protects against cyclosporine-induced nephrotoxicity. Transplantation 67(7), 1065–1068.CrossRefGoogle ScholarPubMed
Lamont, LA & Mathews, KA (2007). Opioids, nonsteroidal anti-inflammatories, and analgesic adjuvants, in lumb and jones. Vet Anesth Analg 4, 241–272.Google Scholar
Lieberthat, W, Menza, SA & Levine, JS (1998). Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells. Am J Physiol 274, F315–F327.Google Scholar
Maestroni, GJ (1993). The immunoneuroendocrine role of melatonin. J Pineal Res 14(1), 1–10.CrossRefGoogle ScholarPubMed
Palla, R, Patrenos, TG, Galigane, R, Brtell, A, Romono, M, Alessandr, M & Bartalla, A (1987). Comparative effects of gentamicin, amikacin and dactimicin on excretion of N-acetyl-beta-D-glucosamidase (NAG) and kidney histological pattern. Drugs Exp Clin Res 13(12), 751–756.Google Scholar
Permpoonputtana, K & Govitrapong, P (2013). The anti-inflammatory effect of melatonin on methamphetamine-induced proinflammatory mediators in human neuroblastoma dopamine sh-sy5y cell lines. Neurotox Res 23(2), 189–199.CrossRefGoogle ScholarPubMed
Poeggeler, B, Saarela, S, Reiter, RJ, Tan, DX & Chen, LD (1993). Melatonin a highly potent endogenous radical scavenger and electron donor: New aspects of the oxidation chemistry of this indole accessed in vitro. Ann NY Acad Sci 1, 57–60.Google Scholar
Pypendop, BH & Ilkiw, JE (2008). Pharmacokinetics of tramadol, and its metabolite O-desmethyl-tramadol, in cats. J Vet Pharmacol Ther 31, 52–59.Google ScholarPubMed
Reiter, RJ (1998). Oxidative damage in the central nervous system: Protection by melatonin. Prog Neurobiol 56(3), 359–384.CrossRefGoogle ScholarPubMed
Reiter, RJ (2000). Melatonin: Lowering the high price of free radicals. News Physiol Sci 15(5), 246–250.Google Scholar
Reiter, RJ, Calvo, JR, Karbownik, M, Qi, W & Tan, DX (2000). Melatonin and its relation to the immune system and inflammation. Ann N Y Acad Sci 917, 376–386.CrossRefGoogle ScholarPubMed
Rodriguez, C, Mayo, JC, Sainz, RM, Antolín, I, Herrera, F, Martín, V & Reiter, RJ (2004). Regulation of antioxidant enzymes: A significant role for melatonin. J Pineal Res 36(1), 1–9.CrossRefGoogle ScholarPubMed
Sakr, SA, El-Messedy, FA & Abdel-Samei, HA (2002). Histopathological and histochemicals effects of gibberellin A3 on the kidney of albino rats. J Egypt German Soc Zool 38, 1–10.Google Scholar
Sakr, S, Okdah, A & El-Abed, F (2003). Gibberellin A3 induced histological and histochemical alterations in the liver of albino rats. ScienceAsia 29, 327–331.CrossRefGoogle Scholar
Seddighi, MR, Egger, CM, Rohrbach, BW, Cox, SK & Doherty, TJ (2009). Effects of tramadol on the minimum alveolar concentration of sevoflurane in dogs. Vet Anaesth Analg 36, 334–340.CrossRefGoogle ScholarPubMed
Sheweita, SA, Almasmari, AA & El-Banna, SG (2018). Tramadol-induced hepato- and nephrotoxicity in rats: Role of curcumin and gallic acid as antioxidants. PLoS ONE 13(8), e0202110.CrossRefGoogle ScholarPubMed
Shimizu, S, Eguchi, Y, Kamiike, W, Waguri, S, Uchiyama, Y, Matsuda, H & Tsujimoto, Y (1996). Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: Possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene 12, 2045–2050.Google ScholarPubMed
Sivaprasada, K, Sombasiva, KR & Ramana, KV (1983). Effect of parathion on tissue ionic changes fish, Channa punctatus. Geobios (Jodhpur) 10, 60–62.Google Scholar
Tahan, G, Gramignoli, R, Marongiu, F, Aktolga, S, Cetinkaya, A, Tahan, V & Dorko, K (2011). Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats. Dig Dis Sci 56(3), 715–720.CrossRefGoogle ScholarPubMed
Tisher, CC & Brenner, BM (1989). Renal Pathology with Clinical and Functional Correlation, Vol. 1. Philadelphia, USA: J. B. Lippincott Company.Google Scholar
Vuong, C, Van Uum, SH, O'Dell, LE, Lutfy, K & Friedman, TC (2010). The effects of opioids and opioid analogs on animal and human endocrine systems [review]. Endocr Rev 31(1), 98–132.CrossRefGoogle Scholar