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Three Dimensional Macroporous Calcium Phosphates Scaffolds for Bone Tissue Engineering

Published online by Cambridge University Press:  21 August 2009

S. Teixeira ,
M. P. Ferraz  and
F. J. Monteiro
S. Teixeira
Affiliation:
INEB — Instituto de Engenharia Biomédica, Divisão de Biomateriais; Universidade do Porto, Portugal Universidade do Porto, Faculdade de Engenharia, Departamento de Engenharia Metalúrgica e Materiais, Portugal
M. P. Ferraz
Affiliation:
Faculdade de Ciências da Saúde daUniversidade Fernando Pessoa, Portugal
F. J. Monteiro
Affiliation:
INEB — Instituto de Engenharia Biomédica, Divisão de Biomateriais; Universidade do Porto, Portugal Universidade do Porto, Faculdade de Engenharia, Departamento de Engenharia Metalúrgica e Materiais, Portugal

Abstract

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Bone tissue engineering is a promising area that aims at developing implants capable of repairing and/ or substituting damaged or lost bone tissue. Ceramics are widely used for bone tissue engineering purposes and in this study, hydroxyapatite porous scaffolds were produced using the polymer replication method. With this method, it was possible to obtain scaffolds with specific demands adequate to tissue engineering purposes namely: macroporosity, microporosity and interconnected porosity. Polyurethane sponges were used as templates and impregnated with a ceramic slurry at different ratios being afterwards sintered following a specific thermal cycle. The characteristics of the hydroxyapatite porous scaffolds were investigated by using scanning electron microscopy and micro computer tomography (μ-CT). Human bone marrow cells (HBMC) were isolated and cultured on the scaffolds for 28 days and SEM was used as a tool to assess cell morphology and distribution.

Type
Materials Sciences
Information
Microscopy and Microanalysis , Volume 15 , Supplement S3 , July 2009 , pp. 61 - 62
Copyright
Copyright © Microscopy Society of America 2009