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Temporal and Spatial Expression Patterns of PDGF Receptors in Embryonic Rat Heart as Detected Through Confocal Scanning Laser Microscopy.

Published online by Cambridge University Press:  02 July 2020

T. Thielen ,
W. Carver ,
D.G. Simpson ,
T.K. Borg ,
L. Terracio  and
R.L. Price
T. Thielen
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC29208
W. Carver
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC29208
D.G. Simpson
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC29208
T.K. Borg
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC29208
L. Terracio
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC29208
R.L. Price
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC29208
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Extract

The active form of platelet derived growth factor (PDGF) is a dimeric combination of two polypeptide chains: PDGF-A and PDGF-B. The protein can exist as a heterodimer (PDGF-AB) or as one of two homodimers (PDGF-AA, PDGF-BB), resulting in three isoforms. Two types of PDGF receptors also exist: PDGFRα and PDGFRß. The PDGFRß binds only the PDGF-B chain, while PDGFRα can bind both PDGF-A and -B chains. Both of these receptors show specific temporal and spatial expression patterns that are related to cellular responses including mitogenesis, cell migration, chemotaxis, adhesion and differentiation in a variety of cell types.

Spontaneous mutants in which the PDGFRα is absent exhibit fatal defects during fetal development in mice. Some of these malformities include cardiac septal, valve, and outflow tract defects. Similar defects occur when the function of PDGF-A is disrupted by blocking antibodies. Disruption of PDGF-B function, results in ventricular and atrial dilation, hyper-trabeculation and reduction of the ventricular wall to the thickness of a single cell layer.

Type
Developmental Biology
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 1166 - 1167
Copyright
Copyright © Microscopy Society of America

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