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The Role of the Centrosome in Development and Progression of Breast Cancer

Published online by Cambridge University Press:  02 July 2020

W. Lingle ,
J. Salisbury ,
S. Barrett ,
V. Negron  and
C. Whitehead
W. Lingle
Affiliation:
Mayo Clinic, Tumor Biology Program, 200 First St. , SW, Rochester, MN , 55905
J. Salisbury
Affiliation:
Mayo Clinic, Tumor Biology Program, 200 First St. , SW, Rochester, MN , 55905
S. Barrett
Affiliation:
Mayo Clinic, Tumor Biology Program, 200 First St. , SW, Rochester, MN , 55905
V. Negron
Affiliation:
Mayo Clinic, Tumor Biology Program, 200 First St. , SW, Rochester, MN , 55905
C. Whitehead
Affiliation:
Mayo Clinic, Tumor Biology Program, 200 First St. , SW, Rochester, MN , 55905
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Abstract

The centrosome is the major microtubule organizing center in most mammalian cells, and as such it determines the number, polarity, and spatial distribution of microtubules (MTs). Interphase MTs, together with actin and intermediate filaments, constitute the cell's cytoskeleton, which dynamically maintains cell polarity and tissue architecture. Interphase cells begin Gl of the cell cycle with one centrosome. During S phase, the centrosome duplicates concomitantly with DNA replication. Duplicated centrosomes usually remain in close proximity to one another until late G2, at which time they separate and then move during prophase to become the poles that organize the bipolar mitotic spindle. During the G2/M transition, interphase MTs depolymerize and a new population of highly dynamic mitotic MTs are nucleated at the spindle poles. The bipolar mitotic spindle apparatus constitutes the machinery that partitions and separates sister chromatids equally between two daughter cells.

Type
The Cell Biology of Cancer (Organized by J. Jerome and B. Gunning)
Information
Microscopy and Microanalysis , Volume 7 , Issue S2: Proceedings: Microscopy & Microanalysis 2001, Microscopy Society of America 59th Annual Meeting, Microbeam Analysis Society 35th Annual Meeting, Long Beach, California August 5-9, 2001 , August 2001 , pp. 582 - 583
Copyright
Copyright © Microscopy Society of America 2001

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References

1.Lingle, W.L. et al., PNAS 95(1998):2950.CrossRefGoogle Scholar
2.Lingle, W.L. and Salisbury, J.L.. American J. Pathol. 155(1999): 1941.CrossRefGoogle Scholar
3.Salisbury, J.L. et al., J. Histochem. Cytochem. 47(1999): 1265CrossRefGoogle Scholar
4. This research was supported by DAMD 17-98-1 -8122 to WLL and NCI CA72836 to JLS.Google Scholar