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Pulmonary Guardians and Special Regulatory Devices in the Lung of Nile Monitor Lizard (Varanus niloticus) with Special Attention to the Communication Between Telocyte, Pericyte, and Immune Cells

Part of: Micrographia Collection

Published online by Cambridge University Press:  27 December 2021

Dalia Mohamedien Open the ORCID record for Dalia Mohamedien [Opens in a new window]  and
Mahmoud Awad Open the ORCID record for Mahmoud Awad [Opens in a new window]
Dalia Mohamedien
Affiliation:
Department of Histology, Faculty of Veterinary Medicine, South Valley University, Qena83523, Egypt
Mahmoud Awad*
Affiliation:
Department of Histology, Faculty of Veterinary Medicine, South Valley University, Qena83523, Egypt
*
*Corresponding author: Mahmoud Awad, E-mail: [email protected]
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Abstract

Monitor lizards are acclimatized to a variety of environments. Most of the monitor species are terrestrial, although there are arboreal and semiaquatic monitors. Such accommodation requires unique cellular structure and regulatory devices in various organs, particularly their lungs. This study aimed to report the pulmonary guardians and special regulatory devices that may guard and promote the function of the lungs of the Nile monitor lizards (Varanus niloticus). Specially structured vessels were recorded in the pulmonary tissue involving atypical glomus vessels, vessels with variable wall thickness, and a venule with specialized internal elastic membrane. Moreover, numerous lung resident guardians could be identified including both alveolar and interstitial macrophages, dendritic cells, mast cells, and B- and T-lymphocytes. Pericytes were demonstrated surrounding the capillary endothelium with a characteristic direct hetero-cellular junction with telocytes. Telocytes established a microenvironment through an indirect hetero-cellular junction with the interstitial macrophage, dendritic cells, and pneumocyte type II. Collectively, these data indicate a significant role played by the specially structured vessels and the resident immune cells in guarding the pulmonary tissue of the Nile monitor lizards and promoting its function. Telocytes are suggested to play a key role in angiogenesis and cellular communication to promote the function of the immune cells.

Keywords

atypical glomus vesseldendritic cellsinterstitial macrophage lymphocytepericytetelocyte
Type
Micrographia
Information
Microscopy and Microanalysis , Volume 28 , Issue 1 , February 2022 , pp. 281 - 287
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

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Footnotes

†

Current address: Department of Animal Physiology, Graduate School of Integrated Science for Life, Hiroshima University, Higashihiroshima 739-8528, Japan.

References

Awad, M, Gaber, W & Ibrahim, D (2019). Onset of appearance and potential significance of telocytes in the developing fetal lung. Microsc Microanal 25, 1246–1256. doi:10.1017/S1431927619014922CrossRefGoogle ScholarPubMed
Bancroft, JD, Layton, C & Suvarna, SK (2013). Bancroft's Theory and Practice of Histological Techniques, 7th ed. London: Elsevier/Churchill Livingstone.Google Scholar
Bennett, D (1995). A Little Book of Monitor Lizards. Aberdeen: Viper Press.Google Scholar
Cheng, H, Jin, C, Wu, J, Zhu, S, Liu, YJ & Chen, J (2017). Guards at the gate: Physiological and pathological roles of tissue-resident innate lymphoid cells in the lung. Protein and Cell 8, 878–895. doi:10.1007/s13238-017-0379-5CrossRefGoogle ScholarPubMed
Holt, PG, Strickland, DH, Wikström, ME & Jahnsen, FL (2008). Regulation of immunological homeostasis in the respiratory tract. Nat Rev Immunol 8, 142–152. doi:10.1038/nri2236CrossRefGoogle ScholarPubMed
Hussein, MM (2020). Structural and functional characteristics of the special regulatory devices in the peripheral pulmonary circulation in rabbits. Protoplasma 257, 755–766. doi:10.1007/s00709-019-01459-yCrossRefGoogle ScholarPubMed
Hussein, MT & Abdel-Maksoud, FM (2020). Structural investigation of epididymal microvasculature and Its relation to telocytes and immune cells in camel. Microsc Microanal 26, 1024–1034. doi:10.1017/S1431927620001786CrossRefGoogle ScholarPubMed
Jiang, XJ, Cretoiu, D, Shen, ZJ & Yang, XJ (2018). An in vitro investigation of telocytes-educated macrophages: Morphology, heterocellular junctions, apoptosis and invasion analysis. J Transl Med 16, 1–12. doi:10.1186/s12967-018-1457-zCrossRefGoogle Scholar
Kopf, M, Schneider, C & Nobs, SP (2015). The development and function of lung-resident macrophages and dendritic cells. Nat Immunol 16, 36–44. doi:10.1038/ni.3052CrossRefGoogle ScholarPubMed
Liegeois, M, Legrand, C, Desmet, CJ, Marichal, T & Bureau, F (2018). The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity. Cell Immunol 330, 91–96. doi:10.1016/j.cellimm.2018.02.001CrossRefGoogle ScholarPubMed
Mohamedien, D (2009). Angioarchitecture of the lungs of the camel. Master's Thesis.Google Scholar
Mokhtar, DM & Hussein, MM (2019). Morphological characteristic and functional dependencies of dendritic cell in developing rabbit lung during fetal and neonatal life. Dev Biol 454, 29–43. doi:10.1016/j.ydbio.2019.06.013CrossRefGoogle ScholarPubMed
Peixoto, D, Klein, W, Abe, AS & Da Cruz, AL (2018). Functional morphology of the lungs of the green iguana, Iguana iguana, in relation of body mass (Squamata: Reptilia). Vertebr Zool 68, 65–82.Google Scholar
Perry, SF (1988). Functional Morphology of the Lungs of the Nile Crocodile, Crocodylus niloticus: Non-Respiratory Parameters.CrossRefGoogle Scholar
Popescu, LM, Gherghiceanu, M, Suciu, LC, Manole, CG & Hinescu, ME (2011). Telocytes and putative stem cells in the lungs: Electron microscopy, electron tomography and laser scanning microscopy. Cell Tissue Res 345, 391–403. doi:10.1007/s00441-011-1229-zCrossRefGoogle ScholarPubMed
Puttur, F, Gregory, LG & Lloyd, CM (2019). Airway macrophages as the guardians of tissue repair in the lung. Immunol Cell Biol 97, 246–257. doi:10.1111/imcb.12235CrossRefGoogle ScholarPubMed
Shi, L, Dong, N, Chen, C & Wang, X (2016). Potential roles of telocytes in lung diseases. Semin Cell Dev Biol 55, 31–39. doi:10.1016/j.semcdb.2016.02.008CrossRefGoogle ScholarPubMed
Smith, RV & Satchell, DG (1987). Histochemistry of the lung of the Australian snake-necked tortoise Chelodina longicollis. J Morphol 192, 257–268. doi:10.1002/jmor.1051920308CrossRefGoogle ScholarPubMed
Zheng, Y, Chen, X, Qian, M, Zhang, M, Zhang, D, Bai, C, Wang, Q & Wang, X (2014). Human lung telocytes could promote the proliferation and angiogenesis of human pulmonary microvascular endothelial cells in vitro. Mol Cell Ther 2, 3. doi:10.1186/2052-8426-2-3CrossRefGoogle ScholarPubMed