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Predictive Value of P53-Positive Cells for Esophageal Cancer Micrometastasis

Published online by Cambridge University Press:  02 July 2020

C. Wei ,
Y. Mao  and
M. Krasna
C. Wei
Affiliation:
Cardiothoracic Molecular Research, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201
Y. Mao
Affiliation:
Cardiothoracic Molecular Research, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201
M. Krasna
Affiliation:
Cardiothoracic Molecular Research, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201
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Extract

Esophageal cancer is the fastest growing malignancy of any tumor in the United States with an increased incidence of adenocarcinoma across all socioeconomic boundaries. The stage and the residual tumor classification are the most important prognostic factors. However, patients with similar stage of disease show a marked difference in survival. Therefore, there are needs to identify new molecular prognostic markers that may help to better assess the survival probability.

The recently introduced genetic diagnosis of cancer micrometastasis is quite attractive because of its high detection sensitivity. Not infrequently, however, there are marked discrepancies between genetic and conventional histologic diagnoses, especially concerning lymph nodes from carcinoma patients. Alterations in the p53 tumor suppressor gene are the most frequent genetic changes found in breast and lung cancer. The p53 gene functions as a negative regulator of cell growth. Alterations in the gene lead to loss of its usual negative growth regulation and more rapid cell proliferation.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 606 - 607
Copyright
Copyright © Microscopy Society of America

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References

References:

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4. This research was supported in part by grants from the NIH (HL03174 & HL61299, C Wei), and University of Maryland School of Medicine.Google Scholar