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The Plain and the Ugly Prion Infected Neuronal Tissue in an Experimental Animal Model; An Electron Microscopic Study.

Published online by Cambridge University Press:  02 July 2020

A. M. Milroy ,
E. Bouzamondo ,
H. J. Ralston III ,
S. B. Prusiner  and
S. J. DeArmond
A. M. Milroy
Affiliation:
Dept. of Anatomy and the W.M.Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA94143
E. Bouzamondo
Affiliation:
Dept. of Neuropathology, University of California, San Francisco, CA94143
H. J. Ralston III
Affiliation:
Dept. of Anatomy and the W.M.Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA94143
S. B. Prusiner
Affiliation:
Dept. of Neurology, Biophysics & Biochemistry University of California, San Francisco, CA94143
S. J. DeArmond
Affiliation:
Dept. of Neuropathology, University of California, San Francisco, CA94143
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Extract

Transmissible encephalopathy of animals (scrapie and bovine spongiform encephalopathy) and of man (Creutzfeldt-Jacob disease, new variant Creutzfeldt-Jacob disease, Kuru, Gerstmann-Straussler-Scheinker disease and familial fatal insomnia) have been well characterized as progressive neurodegenerative diseases, often associated with spongiform degeneration, neuronal loss, reactive astrocytic gliosis and variable amyloid plaques, without any sign of an immune response or inflammatory infiltrates. Prion proteins are elements that propagate variability through multiple biologically active conformers of a host encoded sialoglycoprotein (PrPc). The agent responsible for transmissible encephalopathies is composed mainly, if not exclusively, of an isoform of PrP, designated PrPSc. Extensive information of post-mortem material has been described at the light microscopic level, where the emphasis has been on spongiform tissue and amyloid plaques. Our study provides ultrastructural observations of the central nervous system, specifically of degenerating neurons and their associated changes during the course of scrapie infection in a hamster model.

Type
Microorganisms: The Good, The Bad, The Unusual
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 646 - 647
Copyright
Copyright © Microscopy Society of America

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References

References:

1.DeArmond, S.J. et al., Changes in the Localization of Brain Prion Proteins during Scrapie Infection, Neurology, 37 (1987) 1271–1280.CrossRefGoogle ScholarPubMed
2.Prusiner, S.B., Novel Proteinaceous Infectious Particles cause Scrapie, Science., 216 (1982) 136–144.CrossRefGoogle ScholarPubMed