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Pharmaceutical Polymorphism Studies by Infrared Spectroscopic Imaging

Published online by Cambridge University Press:  02 July 2020

Lori Lewis ,
Peter Troost ,
Donald Lavery  and
Koichi Nishikida
Lori Lewis
Affiliation:
Thermo Spectra-Tech 2 Research Drive Shelton, CT, 06484
Peter Troost
Affiliation:
Thermo Spectra-Tech 2 Research Drive Shelton, CT, 06484
Donald Lavery
Affiliation:
Thermo Spectra-Tech 2 Research Drive Shelton, CT, 06484
Koichi Nishikida
Affiliation:
Thermo Spectra-Tech 2 Research Drive Shelton, CT, 06484
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Abstract

Many drugs are known to crystallize in different polymorphic forms or as solvates. Solubility, melting point, density, hardness, optical properties, vapor pressure, and a host of other physical properties may all vary with polymorphic form. Not only do the various crystal structures of a given pharmaceutical compound affect the efficacy of the drug, but they may also carry enormous legal implications. Much product revenue can depend upon the identification and patent protection of certain polymorphic forms. Thus, the control of crystallization is a very important process parameter, and techniques such as X-ray crystallography, infrared spectroscopy, Raman spectroscopy, and polarized light microscopy are routinely used in the characterization of crystalline drugs.

This presentation will involve the investigation of a variety of pharmaceutical polycrystalline films using infrared (IR) spectroscopic imaging. Preliminary data was collected using a conventional FT-IR microscope with visible polarized light capabilities. Correlating data was then collected using a commercially available IR imaging microscope.

Type
Industrial Applications of Optical Spectroscopy in Microanalysis (Organized by F. Adar and A. Whitley)
Information
Microscopy and Microanalysis , Volume 7 , Issue S2: Proceedings: Microscopy & Microanalysis 2001, Microscopy Society of America 59th Annual Meeting, Microbeam Analysis Society 35th Annual Meeting, Long Beach, California August 5-9, 2001 , August 2001 , pp. 158 - 159
Copyright
Copyright © Microscopy Society of America 2001

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References

references

1.)Haleblian, J. and McCrone, W.. Journal of Pharmaceutical Sciences, 58,911(1969).CrossRefGoogle Scholar
2.)Longmire, M.L.et al., Polymorph Analysis by Dispersive Raman Spectroscopy, Nicolet Application Note, AN-00119.Google Scholar
3.)Schiering, D.W.et al., Infrared Spectroscopic Imaging of Crystal Polymorphism, FACSS (2000).Google Scholar