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Patterning of Surface Chemistry and Topography for Biological Applications

Published online by Cambridge University Press:  02 July 2020

H. G. Craighead ,
R. C. Davis ,
M. Foquet ,
M. Isaacson ,
C. James ,
S. Turner ,
L. Kam ,
J. N. Turner ,
W. Shain  and
G. Banker
H. G. Craighead
Affiliation:
School of Applied and Engineering Physics, Cornell University, Ithaca, NY
R. C. Davis
Affiliation:
School of Applied and Engineering Physics, Cornell University, Ithaca, NY
M. Foquet
Affiliation:
School of Applied and Engineering Physics, Cornell University, Ithaca, NY
M. Isaacson
Affiliation:
School of Applied and Engineering Physics, Cornell University, Ithaca, NY
C. James
Affiliation:
School of Applied and Engineering Physics, Cornell University, Ithaca, NY
S. Turner
Affiliation:
School of Applied and Engineering Physics, Cornell University, Ithaca, NY
L. Kam
Affiliation:
Wadsworth Center and Public Health School, The University of Albany, Troy, NY
J. N. Turner
Affiliation:
Wadsworth Center and Public Health School, The University of Albany, Troy, NY
W. Shain
Affiliation:
Wadsworth Center and Public Health School, The University of Albany, Troy, NY
G. Banker
Affiliation:
Oregon Health Sciences University, Portland, OR
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Extract

The technologies of nanofabrication as applied to inorganic materials and substrates are advanced and continue to develop. These sophisticated processes enable the formation of complex electronic, optical and mechanical devices with feature sizes down to tens of nanometers. Adaptation of these types of processes to surface chemical patterning and topographical patterning provides a new set of experimental tools for investigating biological systems and realizing sensors and devices that require the interaction of biological systems and fluids with inorganic materials and surfaces.

In this talk we discuss methods of pattering self assembled monolayers, proteins and antibodies on silicon and glass surfaces by lithography and microcontact printing. This is of utility in a variety of experiments in cell-surface interactions and in sensor devices. In certain types of devices the manipulation of fluids and sieving of molecules is a critical function such as in DNA sequencing6 by electrophoretic separation.

Type
Miniaturized Artificial Machines in Biology
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 888 - 889
Copyright
Copyright © Microscopy Society of America

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References

1.John, St., et al., J. Neuroscience Meth. 75 (1997) 171.CrossRefGoogle Scholar
2.James, , Davis, R. C., Kam, L., Craighead, H. G., Isaacson, M., Turner, J. N., Shain, W., (to appear in Langmuir).Google Scholar
3. “Diffraction-based cell detection using a microcontact printed antibody grating”, St. John, P. M., Davis, R. C., Cady, N., Czajka, J., Batt, C.A. and Craighead, H. G. (to appear in J. Anal. Chem).Google Scholar
4.Turner, , et al., Pro. SPIE 2978 (1997) 41.CrossRefGoogle Scholar
5. Craighead, Turner, S. W., R. C. Davis, , James, C., Perez, A. M., Kam, L., Shain, W., Turner, J. N., and Banker, G. (to appear in Biomed. Microdevices).Google Scholar
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7.Stern, , Gein, M. W. and Curtin, J. E., J. Vac. Sci. Technol. B 15 (1997) 2887.CrossRefGoogle Scholar
8.Turner, W. and Craighead, H. G., (unpublished).Google Scholar