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Near-infrared Imaging in Stroke Research

Published online by Cambridge University Press:  02 July 2020

R.J. Dempsey ,
R.G. Buice ,
W.C. Symons  and
R.A. Lodder
R.J. Dempsey
Affiliation:
Department of Neurosurgery, University of Wisconsin Clinical Science Center, 600 Highland Ave., H4/338, Madison, WI53792-3232
R.G. Buice
Affiliation:
Division of Medicinal Chemistry and College of Pharmacy, University of Kentucky Medical Center, Lexington, KY40536-0082.
W.C. Symons
Affiliation:
Division of Medicinal Chemistry and College of Pharmacy, University of Kentucky Medical Center, Lexington, KY40536-0082.
R.A. Lodder
Affiliation:
Division of Medicinal Chemistry and College of Pharmacy, University of Kentucky Medical Center, Lexington, KY40536-0082.
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Extract

Accurate and nondestructive measurement of different lipoproteins simultaneously in carotid plaque in stroke patients using near-infrared (IR) imaging spectrometry seems possible for research. The lipoprotein composition of the plaque appears to have an impact on the outcome of the disease process. Carotid atherosclerosis without associated thrombosis is frequently a benign disease that is asymptomatic, although TIAs may be present in other cases. Many patients with carotid atherosclerosis can be treated surgically by endarterectomy with high initial success and favorable long-term prognosis. The acute manifestation of carotid atherosclerosis - stroke - arises when thrombus or ulceration develop. This potentially life-threatening complication probably develops at the site of plaque fissure or rupture. Recent research by others indicates that it is not the severity of stenosis (plaque volume) that determines the outcome: it is the type of stenosis (plaque chemical composition) and the extent of collateral growth.

Type
Optical Microanalysis
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 829 - 830
Copyright
Copyright © Microscopy Society of America 1997

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References

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