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Morphometry of Liver Lesions in an Ultrastructural Pathology Study

Published online by Cambridge University Press:  02 July 2020

A. Singh ,
W.P. Ireland  and
I. Chu
A. Singh
Affiliation:
Atlantic Veterinary College, Charlottetown, PE, CanadaC1A 4P3
W.P. Ireland
Affiliation:
Atlantic Veterinary College, Charlottetown, PE, CanadaC1A 4P3
I. Chu
Affiliation:
Environmental Contaminants Section, Health Canada, Tunney's Pasture, Ottawa, ONK1A 0L2
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Extract

Some pathologic alterations in animal tissue sections, because of low resolution, are not identified using light microscopy. Availability of higher resolution in electron microscopy (EM) confers a decisive role on EM for diagnostic pathology that is well accepted. Much has already been contributed by EM in understanding of liver diseases. However, EM has been further refined by adding a quantitative facet to the results. Morphometric technique allows transfer of facts acquired from 2-dimensional samples, e.g., electron micrographs, to a 3-dimensional perspective. In addition, the technique is valuable in determining the significance of the alterations especially in instances where the changes numerically are either scanty or indistinguishable from a normal appearance of the cells or tissues (Fig. 1).

In our work on the effects of several different PCB congeners, one of the compounds, namely, congener number 153 was studied to obtain morphometric data on the lesions in the liver of rats given the congener in the diets for 13 weeks.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 1062 - 1063
Copyright
Copyright © Microscopy Society of America

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