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Molecular Pathologic Studies on the Echanisms of Radiation-Induced Hematopoietic Cells Apoptosis and the Recovery in Mouse Bone Marrow

Published online by Cambridge University Press:  02 July 2020

D.W. Wang ,
R.Y. Peng  and
C.Q. Xiong
D.W. Wang
Affiliation:
Dept. of experimental Pathology, Institute of Radiation Medicine, Beijing 27- Taiping Road, Beijing100850P.R., China
R.Y. Peng
Affiliation:
Dept. of experimental Pathology, Institute of Radiation Medicine, Beijing 27- Taiping Road, Beijing100850P.R., China
C.Q. Xiong
Affiliation:
Dept. of experimental Pathology, Institute of Radiation Medicine, Beijing 27- Taiping Road, Beijing100850P.R., China
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Extract

There have rarely been reported on radiation induced hematopoietic cells apoptosis and the recovery ,the expression and significance of oncogenes, tumor suppresser genes, hematopoietic grouth factors and their receptors in bone marrow.

By meams of routine pathology, specific stainning, electron microscope, immunocytochemistry, image analysis, in situ hybridization, in situ terminal end labelling, in situ PCR and DNA electrophoresis, The machanisms of hematopoietic cells apoptosis and then recovery in mouse bone marrow were studies through LAC A mouse total body irradiation with 60Co γ -rays.

The results showed: The bone marrow in each radiated group appeared obvious injury and then recovery, and the lessions were the most typical in 5.5Gy irradiation group, the pathologic changes were divided into four phases: namely the phase of hematopoietic cells apoptosis,bone marrow at 6hours after radiation. Furthermore, the higher radiation dose, the more the apoptotic cells were(table l).

Type
Pathology
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 1078 - 1079
Copyright
Copyright © Microscopy Society of America

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