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Microscopic Characterization of Ocular Development and Disease

Published online by Cambridge University Press:  02 July 2020

J. Potts ,
P. Conley  and
R. Champion
J. Potts
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, SC29208
P. Conley
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, SC29208
R. Champion
Affiliation:
Department of Developmental Biology and Anatomy, University of South Carolina, School of Medicine, Columbia, SC29208
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Extract

The embryonic lens contains two populations of cells, lens epithelial cells and lens fiber cells. As the growth of the human lens is linear from the age of 10 to 90, lens epithelial cells divide and differentiate into fiber cells at a uniform rate during adulthood. Any defects that arise during fiber formation will remain in the lens. We postulate that regulation of early lens growth is critical for the onset of cataracts that usually occur later in life. Slowing the growth of the lens could therefore provide a strategy to suppress the formation of cataracts. However, the factor(s) that control lens growth in vivo have not been identified.

We have identified 18 receptor and cytoplasmic kinases present in lens epithelial cells. Using these as potential targets for factors controlling growth, we tested corresponding ligands in a lens epithelial cell proliferation assay. Platelet-derived growth factor (PDGF) proved to promote a growth activity similar to, but distinct from, that of embryo serum.

Type
Applications of Imaging Techniques to the Study of Embryological Development
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1080 - 1081
Copyright
Copyright © Microscopy Society of America

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References

1.Potts, J. D. et al., Curr. Eye Res. 12(1993)759CrossRefGoogle Scholar
2.Potts, J. D. et al., Invest Ophthalmol Vis Sci. 35(1994)3413Google Scholar
3.Potts, J. D. et al., Dev. Biol. 204(1998)277CrossRefGoogle Scholar