Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-24T23:09:52.086Z Has data issue: false hasContentIssue false
  • English
  • Français

Microscopic Analysis of Porous Biodegradable Scaffolds for Tissue Engineering

Published online by Cambridge University Press:  02 July 2020

F. Buevich ,
S. Pulapura  and
J. Kohn
F. Buevich
Affiliation:
Department of Chemistry, Rutgers University, Piscataway, NJ08854.
S. Pulapura
Affiliation:
Department of Chemistry, Rutgers University, Piscataway, NJ08854.
J. Kohn
Affiliation:
Department of Chemistry, Rutgers University, Piscataway, NJ08854.
Get access

Extract

Introduction: There is considerable interest in the use of three-dimensional porous scaffolds for tissue regeneration. The presence of an interconnected framework of pores with large surface area facilitates the formation of extracellular matrix and permits cellular ingrowth into implanted structures. For scaffolds to be useful for tissue regeneration, they must maintain good dimensional stability during the lifetime of the implant. While the initial scaffold architecture is often well characterized, a systematic study of the influence of incubation on the scaffold architecture is critical to ensure that the scaffolds retain their interconnected network of pores during their useful lifetime. Herein, we report on the evaluation of the architecture of polyarylate scaffolds and their stability under in vitro conditions using scanning electron microscopy (SEM).

The polymers used in this study were selected from a library of degradable polyarylates. This library is the first reported combinatorial library of biodegradable condensation polymers.

Type
Biomaterials
Information
Microscopy and Microanalysis , Volume 6 , Issue S2: Proceedings: Microscopy & Microanalysis 2000, Microscopy Society of America 58th Annual Meeting, Microbeam Analysis Society 34th Annual Meeting, Microscopical Society of Canada/Societe de Microscopie de Canada 27th Annual Meeting, Philadelphia, Pennsylvania August 13-17, 2000 , August 2000 , pp. 988 - 989
Copyright
Copyright © Microscopy Society of America

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

References:

1Brocchini, S. et al J. Am. Chem. Soc. 119(19), (1997) 4553.CrossRefGoogle Scholar
2.Asbill, C.S. et al Transactions of the 1999 Annual Meeting of AAPS 1(4), (1999) Abstract # 4140.Google Scholar
3.Lhommeau, C. et al Tissue Eng. 4(4), (1998)468.Google Scholar