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Intraspinal Endodermal Cyst: Ultrastructural Study of Abnormal Cilia

Published online by Cambridge University Press:  23 May 2003

Khang L. Ho ,
Dhananjay A. Chitale  and
Mohamed E. Salama
Khang L. Ho
Affiliation:
Department of Pathology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
Dhananjay A. Chitale
Affiliation:
Department of Pathology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
Mohamed E. Salama
Affiliation:
Department of Pathology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
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Abstract

Abnormal cilia were demonstrated in the lining epithelial cells of three cases of intraspinal endodermal (bronchogenic) cyst. The changes comprised a wide spectrum of ultrastructural abnormalities, including (a) cilia with abnormal axonemal microtubules, (b) swollen cilia, (c) compound cilia with or without excessive ciliary matrix, (d) naked cilia without limiting membrane, and (e) intracytoplasmic cilia and aggregates of microtubules. Of these, compound cilia and swollen cilia were most common. Cilia with dynein arm deficiency were not observed. Ciliary abnormalities found in the present study were very similar to those described in the bronchial epithelium of various diseases. The present findings suggest that the lining epithelium of intraspinal endodermal cyst shares similar ciliogenesis and susceptibility to abnormal ciliary formation as that of the bronchial epithelium.

Keywords

endodermal cystbronchogenic cystultrastructureintraspinalabnormal ciliabronchial epithelium
Type
Research Article
Information
Microscopy and Microanalysis , Volume 9 , Issue 3 , June 2003 , pp. 183 - 189
Copyright
2003 Microscopy Society of America

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