Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-29T01:59:27.729Z Has data issue: false hasContentIssue false
  • English
  • Français

Internalisation of CD46, Membrane Cofactor Protein, As Determinee By Light, Cofocal, and Electron Microscopy

Published online by Cambridge University Press:  02 July 2020

Sarah Ellis ,
Blessing Crimeen ,
Caroline Farrelly  and
Sarah Russell
Sarah Ellis
Affiliation:
Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, 3000, AUSTRALIA.
Blessing Crimeen
Affiliation:
Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, 3000, AUSTRALIA.
Caroline Farrelly
Affiliation:
Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, 3000, AUSTRALIA.
Sarah Russell
Affiliation:
Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, 3000, AUSTRALIA.
Get access

Abstract

Human CD46 (membrane cofactor protein) is expressed on all nucleated human cells and is a cellsurface regulator of activated complement as well as a receptor for both the measles and herpes 6 viruses. CD46 is also expressed in particularly high levels on some tumor cell lines . Complement leads to the recognition of foreign material, targeting it for removal and immune cytolysis. The primary role of CD46 is to bind to one of the complement components, C3b, thereby protecting host cells from autologous complement attack. in addition to its role as a complement regulatory factor, CD46 acts as a measles virus (MV) receptor. Despite the development and use of an effective MV vaccine, at least one million deaths occur each year. MV infection leads to downregulation of cell surface CD46 and immunosupression. MV (and probably also C3b) is internalized shortly after complex formation with CD46, yet, despite much work in this area, precisely how MV enters cells is largely unclear.

Type
Labeling for Microscopy and Correlative Microscopy (Organized By R. Albrecht)
Information
Microscopy and Microanalysis , Volume 7 , Issue S2: Proceedings: Microscopy & Microanalysis 2001, Microscopy Society of America 59th Annual Meeting, Microbeam Analysis Society 35th Annual Meeting, Long Beach, California August 5-9, 2001 , August 2001 , pp. 1040 - 1041
Copyright
Copyright © Microscopy Society of America 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

references

1.Krantic, S.et al., J. General. Virol. 76(1995)2793.CrossRefGoogle Scholar
2.Oldstone., M.B.ACell. 98(1999)629.CrossRefGoogle Scholar
3Seya, T.et al.J.Immunol. 145(1990)238.Google Scholar
4.Seya, T.et al.Int. J. Mol. Med. 1(1998)809.Google Scholar