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The Interactions of Fibrin and Endothelial Cells within a Fibrin Clot

Published online by Cambridge University Press:  02 July 2020

W. G. Jerome ,
R.R. Hantgan  and
S. Handt
W. G. Jerome
Affiliation:
Departments of Pathology, Bowman Gray School of Medicine, Winston-Salem, NC
R.R. Hantgan
Affiliation:
Departments of Biochemistry, Bowman Gray School of Medicine, Winston-Salem, NC
S. Handt
Affiliation:
Institute for Pathology, Aachen University of Technology, Aachen, Germany
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Extract

A life threatening blood clot is the major cause of heart attacks. Thrombolytic therapy attempts to restore blood flow by activating the body's own fibrinolytic system at the site of the occlusive thrombus. However, for unknown reasons, therapy is unsuccessful in greater than 20% of patients. We have previously shown that the endothelial cells lining the wall of the vessel can play a substantial role in inhibiting clot lysis. This is due chiefly to the secretion of inhibitory molecules by endothelial cells. However, endothelial cells also have receptors for fibrin and little is known about how the direct interaction of fibrin with cells may influence lysis. To investigate this we have undertaken a series of microscopic studies to analyse the influence of endothelial cells on clot structure. We report here that endothelial cells can organize clot fibers into tight assemblies. We also show that, at least in culture, fibrin can act in concert with antithrombotic molecules to dramatically affect endothelial structure

Type
Imaging Cells and Organelles
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 233 - 234
Copyright
Copyright © Microscopy Society of America 1997

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