No CrossRef data available.
Article contents
The in Situ structure of a Parkinson's Disease Mutant LRRK2 Bound to Cellular Microtubules Revealed by Cryo-electron Tomography
Published online by Cambridge University Press: 30 July 2020
Abstract
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
- Type
- 3D Structures: From Macromolecular Assemblies to Whole Cells (3DEM FIG)
- Information
- Copyright
- Copyright © Microscopy Society of America 2020
References
Ramirez, Blanca, Lara Ordonez, M., Fdez, A.J., Madero-Perez, E., Gonnelli, J., Drouyer, A., Chartier-Harlin, M., Taymans, M.C., Bubacco, J.M., Greggio, L., et al, E.. (2017). GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2. Hum Mol Genet 26, 2747-2767.10.1093/hmg/ddx161CrossRefGoogle Scholar
Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J.D., Patricelli, M.P., Nomanbhoy, T.K., Alessi, D.R., et al. . (2011). Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat Chem Biol 7, 203-205.10.1038/nchembio.538CrossRefGoogle ScholarPubMed
Di Maio, R., Hoffman, E.K., Rocha, E.M., Keeney, M.T., Sanders, L.H., De Miranda, B.R., Zharikov, A., Van Laar, A., Stepan, A.F., Lanz, T.A., et al. (2018). LRRK2 activation in idiopathic Parkinson's disease. Sci Transl Med 10.10.1126/scitranslmed.aar5429CrossRefGoogle ScholarPubMed
Kett, L.R., Boassa, D., Ho, C.C., Rideout, H.J., Hu, J., Terada, M., Ellisman, M., and Dauer, W.T. (2012). LRRK2 Parkinson disease mutations enhance its microtubule association. Hum Mol Genet 21, 890-899.10.1093/hmg/ddr526CrossRefGoogle ScholarPubMed
Roosen, D.A., and Cookson, M.R. (2016). LRRK2 at the interface of autophagosomes, endosomes and lysosomes. Mol Neurodegener 11, 73.10.1186/s13024-016-0140-1CrossRefGoogle ScholarPubMed
Schmidt, S.H., Knape, M.J., Boassa, D., Mumdey, N., Kornev, A.P., Ellisman, M.H., Taylor, S.S., and Herberg, F.W. (2019). The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGpsi motif in the kinase domain. Proc Natl Acad Sci U S A 116, 14979-14988.10.1073/pnas.1900289116CrossRefGoogle ScholarPubMed
Steger, M., Tonelli, F., Ito, G., Davies, P., Trost, M., Vetter, M., Wachter, S., Lorentzen, E., Duddy, G., Wilson, S., et al. (2016). Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. Elife 5.Google Scholar
You have
Access