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Expression of Chikungunya Virus-like Particles

Published online by Cambridge University Press:  28 September 2012

R. A. Velez ,
A. P. Alves de Matos ,
R. Parreira ,
J. Piedade, B. Matos ,
C. Correia  and
A. Esteves
R. A. Velez
Affiliation:
Grupo de Virologia, Unidade de Microbiologia Médica, UPMM, Instituto de Higiene e Medicina Tropical, UNA, 1349-008 Lisboa, Portugal
A. P. Alves de Matos
Affiliation:
Centro Hospitalar de Lisboa Central—HCC, Serviço de Anatomia Patológica, R. da Beneficência 8, 1069-166 Lisboa and Centro de Estudos do Ambiente e do Mar (CESAM)—Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1149-016, Lisboa, Portugal
R. Parreira
Affiliation:
Grupo de Virologia, Unidade de Microbiologia Médica, UPMM, Instituto de Higiene e Medicina Tropical, UNA, 1349-008 Lisboa, Portugal
J. Piedade, B. Matos
Affiliation:
Centro Hospitalar de Lisboa Central– HCC, Serviço de Anatomia Patológica, R. da Beneficência 8, 1069-166 Lisboa, Portugal
C. Correia
Affiliation:
Centro Hospitalar de Lisboa Central– HCC, Serviço de Anatomia Patológica, R. da Beneficência 8, 1069-166 Lisboa, Portugal
A. Esteves
Affiliation:
Grupo de Virologia, Unidade de Microbiologia Médica, UPMM, Instituto de Higiene e Medicina Tropical, UNA, 1349-008 Lisboa, Portugal

Abstract

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Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus responsible for painful disabling polyarthritis, undergoing re-emergence in the Indian Ocean and the Asian continent. Travelling and changing patterns of vector distribution, and abundance due to climate changes, make CHIKV a global threat without effective control strategies. One approach to reduce the CHIKV burden is the development of a vaccine. Virus-like particles (VLPs) are a safe and highly effective class of subunit vaccines that mimic the overall structure of virus particles. Accordingly, we aim to produce CHIKV VLPs in a baculovirus-insect cell system, well known for allowing high yields of recombinant protein expression, to be used as a vaccine preparation.

Type
Life Sciences
Information
Microscopy and Microanalysis , Volume 18 , Supplement S5: Portuguese Supplement , August 2012 , pp. 59 - 60
Copyright
Copyright © Microscopy Society of America 2012