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Erythrocyte–Platelet Interaction in Uncomplicated Pregnancy

Published online by Cambridge University Press:  03 December 2014

Albe C. Swanepoel  and
Etheresia Pretorius
Albe C. Swanepoel
Affiliation:
Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Private Bag x323; Arcadia 0007, South Africa
Etheresia Pretorius*
Affiliation:
Department of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Private Bag x323; Arcadia 0007, South Africa
*
*Corresponding author. [email protected]
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Abstract

Maternal and fetal requirements during uncomplicated pregnancy are associated with changes in the hematopoietic system. Platelets and erythrocytes [red blood cells (RBCs)], and especially their membranes, are involved in coagulation, and their interactions may provide reasons for the changed hematopoietic system during uncomplicated pregnancy. We review literature regarding RBC and platelet membrane structure and interactions during hypercoagulability and hormonal changes. We then study interactions between RBCs and platelets in uncomplicated pregnancy, as their interactions may be one of the reasons for increased hypercoagulability during uncomplicated pregnancy. Scanning electron microscopy was used to study whole blood smears from 90 pregnant females in different phases of pregnancy. Pregnancy-specific interaction was seen between RBCs and platelets. Typically, one or more platelets interacted through platelet spreading and pseudopodia formation with a single RBC. However, multiple interactions with RBCs were also shown for a single platelet. Specific RBC–platelet interaction seen during uncomplicated pregnancy may be caused by increased estrogen and/or increased fibrinogen concentrations. This interaction may contribute to the hypercoagulable state associated with healthy and uncomplicated pregnancy and may also play a fundamental role in gestational thrombocytopenia.

Keywords

uncomplicated pregnancyerythrocytesplateletsscanning electron microscopy
Type
Biological Applications
Information
Microscopy and Microanalysis , Volume 20 , Issue 6 , December 2014 , pp. 1848 - 1860
Copyright
© Microscopy Society of America 2014 

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