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ERK activation in noradrenergic and serotonergic brainstem nuclei in chronic pain upon noxious stimulation and antidepressants treatment

Published online by Cambridge University Press:  21 August 2009

G. Borges ,
E. Berrocoso ,
A. Ortega-Alvaro ,
J. A. Micó  and
F. L. Neto
G. Borges
Affiliation:
Instituto de Histologia e Embriologia, Faculdade de Medicina do Porto e Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal
E. Berrocoso
Affiliation:
Departamento de Neurociencias (Farmacología y Psiquiatria), Grupo de Investigación y Dessarollo en Neuropsicofarmacología, Facultad de Medicina, Universitad de Cádiz, Cádiz, España
A. Ortega-Alvaro
Affiliation:
Departamento de Neurociencias (Farmacología y Psiquiatria), Grupo de Investigación y Dessarollo en Neuropsicofarmacología, Facultad de Medicina, Universitad de Cádiz, Cádiz, España
J. A. Micó
Affiliation:
Departamento de Neurociencias (Farmacología y Psiquiatria), Grupo de Investigación y Dessarollo en Neuropsicofarmacología, Facultad de Medicina, Universitad de Cádiz, Cádiz, España
F. L. Neto
Affiliation:
Instituto de Histologia e Embriologia, Faculdade de Medicina do Porto e Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Portugal

Abstract

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Chronic neuropathic pain is a pathology that affects thousands of people worldwide. Antidepressants have been prescribed for the treatment of this sort of pain but the mechanisms underlying their analgesic action remain unknown. Extracellular-signal regulated kinases (ERKs) are being implicated in pain transmission and modulation as well as in the pathophysiology of depression. In order to clarify some of the mechanisms which might be related to the analgesic effect of antidepressants, we started by evaluating possible changes in the pattern of activation of ERKs in rats with chronic constriction injury (CCI), an experimental model of chronic

Type
Life Sciences
Information
Microscopy and Microanalysis , Volume 15 , Supplement S3 , July 2009 , pp. 7 - 8
Copyright
Copyright © Microscopy Society of America 2009