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Early Apoptotic Changes in the Leukocytes of Rhesus Macaques Challenged With Chimeric Simian/Human Immunodeficiency Virus (Shiv)

Published online by Cambridge University Press:  02 July 2020

N.J. Bryant ,
L.V. Asher ,
M. Lewis ,
J. Mascola ,
C. Carpenter  and
C. Hanson
N.J. Bryant
Affiliation:
Division of Pathology, Walter Reed Army Institute of Research, Washington, DC, 20307-5100
L.V. Asher
Affiliation:
Division of Pathology, Walter Reed Army Institute of Research, Washington, DC, 20307-5100
M. Lewis
Affiliation:
Division of Pathology, Walter Reed Army Institute of Research, Washington, DC, 20307-5100
J. Mascola
Affiliation:
Division of Pathology, Walter Reed Army Institute of Research, Washington, DC, 20307-5100
C. Carpenter
Affiliation:
Division of Pathology, Walter Reed Army Institute of Research, Washington, DC, 20307-5100
C. Hanson
Affiliation:
Division of Pathology, Walter Reed Army Institute of Research, Washington, DC, 20307-5100
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Extract

Introduction

Chimeric Simian/Human Immunodeficiency Viruses (SHIV) causes persistent infection characterized by CD4+ T cell lymphopenia in rhesus monkeys. The SHIV model infection closely resembles HIV-1 infection and disease in humans, except that it progresses at an accelerated rate. During the early stages of HIV-1 infection, viral replication is at its highest rate and there is a rapid decline of the immune system. Cell death induced by apoptosis, a feature in the pathogenesis of acquired immunodeficiency syndrome (AIDS) and AIDS-like syndromes of many lentiviral infections, is thought to be important in the progressive decline of lymphocytes and the cell mediated immunity of infected individuals. The apoptosis is not specific for lymphocytes, this phenomenon also occurs in numerous cell types of the immune system, including the polymorphonuclear leukocytes. Abnormalities of neutrophil function and number because of HIV-1 and other retroviral infections have been recognized.

Type
Pathology of Aids and Related Conditions
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1100 - 1101
Copyright
Copyright © Microscopy Society of America

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