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Developing Physicochemical Characterization and In vitro Release Test Methods to Probe Drug Release Mechanism from Multivesicular Liposomes

Published online by Cambridge University Press:  01 August 2018

Soumyarwit Manna ,
Yong Wu ,
Peter Petrochenko ,
Bonhye Koo ,
Lynn Chen ,
Yixuan Dong ,
Xiaoming Xu ,
Stephanie Choi ,
Darby Kozak  and
Yan Wang
...Show all authors
Soumyarwit Manna
Affiliation:
Division of Therapeutic Performance, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland20993, United States Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland20993, United States
Yong Wu
Affiliation:
Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland20993, United States
Peter Petrochenko
Affiliation:
Division of Therapeutic Performance, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland20993, United States
Bonhye Koo
Affiliation:
Division of Therapeutic Performance, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland20993, United States Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland20993, United States
Lynn Chen
Affiliation:
Division of Therapeutic Performance, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland20993, United States Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland20993, United States
Yixuan Dong
Affiliation:
Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland20993, United States
Xiaoming Xu
Affiliation:
Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland20993, United States
Stephanie Choi
Affiliation:
Division of Therapeutic Performance, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland20993, United States
Darby Kozak
Affiliation:
Division of Therapeutic Performance, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland20993, United States
Yan Wang
Affiliation:
Division of Therapeutic Performance, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland20993, United States
Jiwen Zheng
Affiliation:
Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland20993, United States

Abstract

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Abstract
Information
Microscopy and Microanalysis , Volume 24 , Supplement S1: Proceedings of Microscopy & Microanalysis 2018 , August 2018 , pp. 1426 - 1427
Copyright
© Microscopy Society of America 2018 

References

[1] Chahar, P Cumminngs, K III J. Pain Res 5 2012) p. 257–264.Google Scholar
[2] Mantripragada, S Prog Lipid Res 41(5 2002) p. 392–406.Google Scholar
[3] This project was supported in part by an appointment to the Research Participation Program at Center for Drug Evaluation and Research administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and FDA. The authors would like to acknowledge FDA Advanced Characterization Facility (ACF), CDRH/OSEL/DBCMS and CDER/OPQ/OTR for instrument use. Soumyarwit Manna, Yong Wu, Bonhye Koo, Lynn Chen and Yixuan Dong were supported in part by an appointment to the Research Participation Program at the U.S. Food and Drug Administration (FDA), administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and the FDA..Google Scholar